TY - JOUR
T1 - Brief communication
T2 - Duration of platelet dysfunction after a 7-day course of ibuprofen
AU - Goldenberg, Neil A.
AU - Jacobson, Linda
AU - Manco-Johnson, Marilyn J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2005/4/1
Y1 - 2005/4/1
N2 - Background: Despite a paucity of evidence, clinicians routinely advise that patients discontinue using nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, at least 1 week before most surgical procedures. Objective: To define the duration of ibuprofen-induced platelet dysfunction. Design: Prospective cohort study. Setting: Denver/Aurora, Colorado. Participants: 11 healthy adult volunteers. Measurements: Individuals were tested at baseline and serially after completion of a 7-day course of ibuprofen (600 mg orally every 8 hours). The platelet function analyzer (PFA-100, Dade Behring, Newark, Delaware), a test that has replaced the bleeding time in many clinical settings, was used. Results: All participants exhibited normal platelet function before starting ibuprofen. Platelet dysfunction was apparent after completion of the ibuprofen course in 7 of the 11 participants and normalized by 24 hours after the last ibuprofen dose. Limitations: The sample size in this study was small, and no participants had a major illness. Correlation between PFA-100 results and clinical bleeding has not been established. Conclusions: Platelet function seems to normalize within 24 hours after cessation of regular ibuprofen use in healthy individuals. Further studies are warranted to provide a rational basis for tirring of NSAID withdrawal in a range of patients undergoing surgery.
AB - Background: Despite a paucity of evidence, clinicians routinely advise that patients discontinue using nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, at least 1 week before most surgical procedures. Objective: To define the duration of ibuprofen-induced platelet dysfunction. Design: Prospective cohort study. Setting: Denver/Aurora, Colorado. Participants: 11 healthy adult volunteers. Measurements: Individuals were tested at baseline and serially after completion of a 7-day course of ibuprofen (600 mg orally every 8 hours). The platelet function analyzer (PFA-100, Dade Behring, Newark, Delaware), a test that has replaced the bleeding time in many clinical settings, was used. Results: All participants exhibited normal platelet function before starting ibuprofen. Platelet dysfunction was apparent after completion of the ibuprofen course in 7 of the 11 participants and normalized by 24 hours after the last ibuprofen dose. Limitations: The sample size in this study was small, and no participants had a major illness. Correlation between PFA-100 results and clinical bleeding has not been established. Conclusions: Platelet function seems to normalize within 24 hours after cessation of regular ibuprofen use in healthy individuals. Further studies are warranted to provide a rational basis for tirring of NSAID withdrawal in a range of patients undergoing surgery.
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U2 - 10.7326/0003-4819-142-7-200504050-00009
DO - 10.7326/0003-4819-142-7-200504050-00009
M3 - Article
C2 - 15809462
AN - SCOPUS:15944391012
SN - 0003-4819
VL - 142
SP - 506
EP - 509
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 7
ER -