Abstract
Risk for Alzheimer's disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a person's age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimer's disease.
Original language | English (US) |
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Pages (from-to) | 197-199 |
Number of pages | 3 |
Journal | Current Alzheimer Research |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - May 2010 |
Keywords
- Animal models
- Dentate gyrus/CA3
- Hippocampus
- Memory
- Mild cognitive impairment
- Neuroimaging
- Pattern completion
- Pattern separation
ASJC Scopus subject areas
- Neurology
- Clinical Neurology