Breastfeeding is associated with the production of type i interferon in infants infected with influenza virus

Guillermina A. Melendi, Silvina Coviello, Niranjan Bhat, Johanna Zea-Hernandez, Fausto M. Ferolla, Fernando P. Polack

Research output: Contribution to journalArticle

Abstract

Background: Breast milk-mediated protection against respiratory viruses is well established. However, protective mechanisms are unclear. Type I interferons (IFN) mediate host defence against respiratory viruses, particularly influenza virus. The relationship among type I IFN, respiratory viral infections and breastfeeding has not been explored. Methods: Type I IFN responses were studied by ELISA and real time PCR in nasal secretions of infants experiencing their first respiratory infection. Modulation of IFN by breastfeeding and other variables affecting severity during viral infection was explored. Results: One hundred and twenty infants were positive by RT-PCR for influenza virus (n = 24), human metapneumovirus (hMPV) (n = 30) or respiratory syncytial virus (RSV) (n = 66). Type I IFNs were detected more frequently in infants infected with influenza virus than in those infected with RSV or hMPV. Breastfeeding promoted higher rates and levels of type I IFN only in infants infected with influenza virus. No effect on IFN production was observed for age, gender or smoking. Conclusion: Our study confirms that type I IFN production is detected more frequently in infants infected with influenza virus. Importantly, higher rates and levels of type I IFN in these infants are associated with breastfeeding. These observations suggest that breast milk can protect against respiratory viruses by activating innate antiviral mechanisms in the host.

Original languageEnglish (US)
Pages (from-to)1517-1521
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume99
Issue number10
DOIs
StatePublished - Oct 2010

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Interferon Type I
Breast Feeding
Orthomyxoviridae
Interferons
Metapneumovirus
Respiratory Syncytial Viruses
Human Milk
Virus Diseases
Viruses
Respiratory Tract Infections
Nose
Antiviral Agents
Real-Time Polymerase Chain Reaction
Smoking
Enzyme-Linked Immunosorbent Assay
Polymerase Chain Reaction

Keywords

  • Breast milk
  • Influenza
  • Interferon

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Breastfeeding is associated with the production of type i interferon in infants infected with influenza virus. / Melendi, Guillermina A.; Coviello, Silvina; Bhat, Niranjan; Zea-Hernandez, Johanna; Ferolla, Fausto M.; Polack, Fernando P.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 99, No. 10, 10.2010, p. 1517-1521.

Research output: Contribution to journalArticle

Melendi, Guillermina A. ; Coviello, Silvina ; Bhat, Niranjan ; Zea-Hernandez, Johanna ; Ferolla, Fausto M. ; Polack, Fernando P. / Breastfeeding is associated with the production of type i interferon in infants infected with influenza virus. In: Acta Paediatrica, International Journal of Paediatrics. 2010 ; Vol. 99, No. 10. pp. 1517-1521.
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