@article{f640fc21ac544a29ad78875464c19884,
title = "Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy",
abstract = "The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form of prolactin is pathogenic and suggests that breastfeeding may worsen peripartum cardiomyopathy by increasing prolactin, while bromocriptine, which blocks prolactin release, may be therapeutic. An autoimmune etiology has also been proposed. The authors investigated the impact of breastfeeding on cellular immunity and myocardial recovery for women with peripartum cardiomyopathy in the IPAC (Investigations in Pregnancy Associated Cardiomyopathy) study. Women who breastfed had elevated prolactin, and prolactin levels correlated with elevations in CD8+ T cells. However, despite elevated prolactin and cytotoxic T cell subsets, myocardial recovery was not impaired in breastfeeding women.",
keywords = "breastfeeding, immune activation, peripartum cardiomyopathy",
author = "{IPAC Investigators} and Agnes Koczo and Amy Marino and Arun Jeyabalan and Uri Elkayam and Cooper, {Leslie T.} and James Fett and Joan Briller and Eileen Hsich and Lori Blauwet and Charles McTiernan and Morel, {Penelope A.} and Karen Hanley-Yanez and McNamara, {Dennis M.} and McNamara, {Dennis M.} and Fett, {James D.} and Jessica Pisarcik and John Gorcsan and Erik Schelbert and Rami Alharethi and Kismet Rasmusson and Kim Brunisholz and Amy Butler and Deborah Budge and Kfoury, {A. G.} and Benjamin Horne and Joe Tuinei and Heather Brown and Julie Damp and Naftilan, {Allen J.} and Jill Russell and Darla Freehardt and Cynthia Oblak and Greg Ewald and Donna Whitehead and Jean Flanagan and Anne Platts and Jorge Caro and Stephanie Mullin and Givertz, {Michael M.} and Anello, {M. Susan} and Navin Rajagopalan and David Booth and Tiffany Sandlin and Wendy Wijesiri and Blauwet, {Lori A.} and Joann Brunner and Mary Phelps and Ruth Kempf and Stacy Fisher and Wittstein, {Ilan S.}",
note = "Funding Information: This investigation was supported by the National Heart, Lung, and Blood Institute through contract HL102429. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = jun,
doi = "10.1016/j.jacbts.2019.01.010",
language = "English (US)",
volume = "4",
pages = "291--300",
journal = "JACC: Basic to Translational Science",
issn = "2452-302X",
publisher = "Elsevier Inc.",
number = "3",
}