Breastfeeding associated with higher lung function in African American youths with asthma

Sam S. Oh, Randal Du, Andrew M. Zeiger, Meghan E. McGarry, Donglei Hu, Neeta Thakur, Maria Pino-Yanes, Joshua M. Galanter, Celeste Eng, Katherine Keiko Nishimura, Scott Huntsman, Harold J. Farber, Kelley Meade, Pedro Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A. Lenoir, Jean G. Ford, Emerita Brigino-Buenaventura, William Rodriguez-Cintron & 6 others Shannon M. Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Keoki Williams, Rajesh Kumar, Esteban G. Burchard

Research output: Contribution to journalArticle

Abstract

Objective: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. Methods: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8–21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. Results: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. Conclusion: Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Asthma
DOIs
StateAccepted/In press - Feb 9 2017

Fingerprint

Breast Feeding
African Americans
Asthma
Hispanic Americans
Lung
Forced Expiratory Volume
Ethnic Groups
Genes
Linear Models
History

Keywords

  • Asthma
  • breastfeeding
  • exacerbations
  • genetic admixture
  • Hispanics
  • lung function
  • minority

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Oh, S. S., Du, R., Zeiger, A. M., McGarry, M. E., Hu, D., Thakur, N., ... Burchard, E. G. (Accepted/In press). Breastfeeding associated with higher lung function in African American youths with asthma. Journal of Asthma, 1-10. https://doi.org/10.1080/02770903.2016.1266496

Breastfeeding associated with higher lung function in African American youths with asthma. / Oh, Sam S.; Du, Randal; Zeiger, Andrew M.; McGarry, Meghan E.; Hu, Donglei; Thakur, Neeta; Pino-Yanes, Maria; Galanter, Joshua M.; Eng, Celeste; Nishimura, Katherine Keiko; Huntsman, Scott; Farber, Harold J.; Meade, Kelley; Avila, Pedro; Serebrisky, Denise; Bibbins-Domingo, Kirsten; Lenoir, Michael A.; Ford, Jean G.; Brigino-Buenaventura, Emerita; Rodriguez-Cintron, William; Thyne, Shannon M.; Sen, Saunak; Rodriguez-Santana, Jose R.; Williams, Keoki; Kumar, Rajesh; Burchard, Esteban G.

In: Journal of Asthma, 09.02.2017, p. 1-10.

Research output: Contribution to journalArticle

Oh, SS, Du, R, Zeiger, AM, McGarry, ME, Hu, D, Thakur, N, Pino-Yanes, M, Galanter, JM, Eng, C, Nishimura, KK, Huntsman, S, Farber, HJ, Meade, K, Avila, P, Serebrisky, D, Bibbins-Domingo, K, Lenoir, MA, Ford, JG, Brigino-Buenaventura, E, Rodriguez-Cintron, W, Thyne, SM, Sen, S, Rodriguez-Santana, JR, Williams, K, Kumar, R & Burchard, EG 2017, 'Breastfeeding associated with higher lung function in African American youths with asthma', Journal of Asthma, pp. 1-10. https://doi.org/10.1080/02770903.2016.1266496
Oh, Sam S. ; Du, Randal ; Zeiger, Andrew M. ; McGarry, Meghan E. ; Hu, Donglei ; Thakur, Neeta ; Pino-Yanes, Maria ; Galanter, Joshua M. ; Eng, Celeste ; Nishimura, Katherine Keiko ; Huntsman, Scott ; Farber, Harold J. ; Meade, Kelley ; Avila, Pedro ; Serebrisky, Denise ; Bibbins-Domingo, Kirsten ; Lenoir, Michael A. ; Ford, Jean G. ; Brigino-Buenaventura, Emerita ; Rodriguez-Cintron, William ; Thyne, Shannon M. ; Sen, Saunak ; Rodriguez-Santana, Jose R. ; Williams, Keoki ; Kumar, Rajesh ; Burchard, Esteban G. / Breastfeeding associated with higher lung function in African American youths with asthma. In: Journal of Asthma. 2017 ; pp. 1-10.
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AU - Oh, Sam S.

AU - Du, Randal

AU - Zeiger, Andrew M.

AU - McGarry, Meghan E.

AU - Hu, Donglei

AU - Thakur, Neeta

AU - Pino-Yanes, Maria

AU - Galanter, Joshua M.

AU - Eng, Celeste

AU - Nishimura, Katherine Keiko

AU - Huntsman, Scott

AU - Farber, Harold J.

AU - Meade, Kelley

AU - Avila, Pedro

AU - Serebrisky, Denise

AU - Bibbins-Domingo, Kirsten

AU - Lenoir, Michael A.

AU - Ford, Jean G.

AU - Brigino-Buenaventura, Emerita

AU - Rodriguez-Cintron, William

AU - Thyne, Shannon M.

AU - Sen, Saunak

AU - Rodriguez-Santana, Jose R.

AU - Williams, Keoki

AU - Kumar, Rajesh

AU - Burchard, Esteban G.

PY - 2017/2/9

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N2 - Objective: In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma. Methods: As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8–21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations. Results: Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only. Conclusion: Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.

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