Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Joanne Kotsopoulos, Jan Lubinski, Leonardo Salmena, Henry T. Lynch, Charmaine Kim-Sing, William D. Foulkes, Parviz Ghadirian, Susan L. Neuhausen, Rochelle Demsky, Nadine Tung, Peter Ainsworth, Leigha Senter, Andrea Eisen, Charis Eng, Christian Singer, Ophira Ginsburg, Joanne Blum, Tomasz Huzarski, Aletta Poll, Ping SunSteven A. Narod, Mary Daly, Dawna Gilchrist, Taya Fallen, Albert Chudley, John Lunn, Talia Donenberg, Beth Karlan, Raluca N. Kurz, Jeffrey Weitzel, Howard Saal, Dana Zakalik, Susan Friedman, Judy Garber, Gad Rennert, Kevin Sweet, Ruth Gershoni-Baruch, Christine Rappaport, Edmond Lemire, Dominique Stoppa-Lyonnet, Olufunmilayo I. Olopade, Sofia Merajver, Louise Bordeleau, Carey A. Cullinane, Eitan Friedman, Wendy McKinnon, Marie Wood, Daniel Rayson, Wendy Meschino, Jane McLennan, Josephine Wagner Costalas, Robert E. Reilly, Tuya Pal, Susan Vadaparampil, Kenneth Offit, Mark Robson, Noah Kauff, Jan Klijn, Pal Moller, David M Euhus, Ava Kwong, Claudine Isaacs, Fergus Couch, Siranoush Manoukian, Cezary Cybulski, Jacek Gronwald, Tomasz Byrski, Seema Panchal, Sonia Nanda, Kelly Metcalfe, Barry Rosen, Susan Randall, Adriana Valentini, Marcia Llacuachaqui, Alejandra Ragone, Jennifer Ng, Kristi De Buono, Kate Bisnaire, Dina Nikitina, Anneli Loo, Bita Khorram, Dina Gordon, Courtney May, Michelle Jones, Jose Miguel Lozano, Joanne Kotsopoulos, Charis Eng, J. Sondra, Stephen R. Hardis, Susan L. Neuhausen, Steven Narod

Research output: Contribution to journalArticle

Abstract

Introduction: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers.Methods: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Results: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43).Conclusions: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.

Original languageEnglish (US)
Article numberR42
JournalBreast Cancer Research
Volume14
Issue number2
DOIs
StatePublished - Mar 9 2012
Externally publishedYes

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Breast Feeding
Breast Neoplasms
Mutation
Risk Reduction Behavior
Live Birth
Parity
Case-Control Studies
Logistic Models
Parturition

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Kotsopoulos, J., Lubinski, J., Salmena, L., Lynch, H. T., Kim-Sing, C., Foulkes, W. D., ... Narod, S. (2012). Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research, 14(2), [R42]. https://doi.org/10.1186/bcr3138

Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. / Kotsopoulos, Joanne; Lubinski, Jan; Salmena, Leonardo; Lynch, Henry T.; Kim-Sing, Charmaine; Foulkes, William D.; Ghadirian, Parviz; Neuhausen, Susan L.; Demsky, Rochelle; Tung, Nadine; Ainsworth, Peter; Senter, Leigha; Eisen, Andrea; Eng, Charis; Singer, Christian; Ginsburg, Ophira; Blum, Joanne; Huzarski, Tomasz; Poll, Aletta; Sun, Ping; Narod, Steven A.; Daly, Mary; Gilchrist, Dawna; Fallen, Taya; Chudley, Albert; Lunn, John; Donenberg, Talia; Karlan, Beth; Kurz, Raluca N.; Weitzel, Jeffrey; Saal, Howard; Zakalik, Dana; Friedman, Susan; Garber, Judy; Rennert, Gad; Sweet, Kevin; Gershoni-Baruch, Ruth; Rappaport, Christine; Lemire, Edmond; Stoppa-Lyonnet, Dominique; Olopade, Olufunmilayo I.; Merajver, Sofia; Bordeleau, Louise; Cullinane, Carey A.; Friedman, Eitan; McKinnon, Wendy; Wood, Marie; Rayson, Daniel; Meschino, Wendy; McLennan, Jane; Costalas, Josephine Wagner; Reilly, Robert E.; Pal, Tuya; Vadaparampil, Susan; Offit, Kenneth; Robson, Mark; Kauff, Noah; Klijn, Jan; Moller, Pal; Euhus, David M; Kwong, Ava; Isaacs, Claudine; Couch, Fergus; Manoukian, Siranoush; Cybulski, Cezary; Gronwald, Jacek; Byrski, Tomasz; Panchal, Seema; Nanda, Sonia; Metcalfe, Kelly; Rosen, Barry; Randall, Susan; Valentini, Adriana; Llacuachaqui, Marcia; Ragone, Alejandra; Ng, Jennifer; Buono, Kristi De; Bisnaire, Kate; Nikitina, Dina; Loo, Anneli; Khorram, Bita; Gordon, Dina; May, Courtney; Jones, Michelle; Lozano, Jose Miguel; Kotsopoulos, Joanne; Eng, Charis; Sondra, J.; Hardis, Stephen R.; Neuhausen, Susan L.; Narod, Steven.

In: Breast Cancer Research, Vol. 14, No. 2, R42, 09.03.2012.

Research output: Contribution to journalArticle

Kotsopoulos, J, Lubinski, J, Salmena, L, Lynch, HT, Kim-Sing, C, Foulkes, WD, Ghadirian, P, Neuhausen, SL, Demsky, R, Tung, N, Ainsworth, P, Senter, L, Eisen, A, Eng, C, Singer, C, Ginsburg, O, Blum, J, Huzarski, T, Poll, A, Sun, P, Narod, SA, Daly, M, Gilchrist, D, Fallen, T, Chudley, A, Lunn, J, Donenberg, T, Karlan, B, Kurz, RN, Weitzel, J, Saal, H, Zakalik, D, Friedman, S, Garber, J, Rennert, G, Sweet, K, Gershoni-Baruch, R, Rappaport, C, Lemire, E, Stoppa-Lyonnet, D, Olopade, OI, Merajver, S, Bordeleau, L, Cullinane, CA, Friedman, E, McKinnon, W, Wood, M, Rayson, D, Meschino, W, McLennan, J, Costalas, JW, Reilly, RE, Pal, T, Vadaparampil, S, Offit, K, Robson, M, Kauff, N, Klijn, J, Moller, P, Euhus, DM, Kwong, A, Isaacs, C, Couch, F, Manoukian, S, Cybulski, C, Gronwald, J, Byrski, T, Panchal, S, Nanda, S, Metcalfe, K, Rosen, B, Randall, S, Valentini, A, Llacuachaqui, M, Ragone, A, Ng, J, Buono, KD, Bisnaire, K, Nikitina, D, Loo, A, Khorram, B, Gordon, D, May, C, Jones, M, Lozano, JM, Kotsopoulos, J, Eng, C, Sondra, J, Hardis, SR, Neuhausen, SL & Narod, S 2012, 'Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers', Breast Cancer Research, vol. 14, no. 2, R42. https://doi.org/10.1186/bcr3138
Kotsopoulos J, Lubinski J, Salmena L, Lynch HT, Kim-Sing C, Foulkes WD et al. Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research. 2012 Mar 9;14(2). R42. https://doi.org/10.1186/bcr3138
Kotsopoulos, Joanne ; Lubinski, Jan ; Salmena, Leonardo ; Lynch, Henry T. ; Kim-Sing, Charmaine ; Foulkes, William D. ; Ghadirian, Parviz ; Neuhausen, Susan L. ; Demsky, Rochelle ; Tung, Nadine ; Ainsworth, Peter ; Senter, Leigha ; Eisen, Andrea ; Eng, Charis ; Singer, Christian ; Ginsburg, Ophira ; Blum, Joanne ; Huzarski, Tomasz ; Poll, Aletta ; Sun, Ping ; Narod, Steven A. ; Daly, Mary ; Gilchrist, Dawna ; Fallen, Taya ; Chudley, Albert ; Lunn, John ; Donenberg, Talia ; Karlan, Beth ; Kurz, Raluca N. ; Weitzel, Jeffrey ; Saal, Howard ; Zakalik, Dana ; Friedman, Susan ; Garber, Judy ; Rennert, Gad ; Sweet, Kevin ; Gershoni-Baruch, Ruth ; Rappaport, Christine ; Lemire, Edmond ; Stoppa-Lyonnet, Dominique ; Olopade, Olufunmilayo I. ; Merajver, Sofia ; Bordeleau, Louise ; Cullinane, Carey A. ; Friedman, Eitan ; McKinnon, Wendy ; Wood, Marie ; Rayson, Daniel ; Meschino, Wendy ; McLennan, Jane ; Costalas, Josephine Wagner ; Reilly, Robert E. ; Pal, Tuya ; Vadaparampil, Susan ; Offit, Kenneth ; Robson, Mark ; Kauff, Noah ; Klijn, Jan ; Moller, Pal ; Euhus, David M ; Kwong, Ava ; Isaacs, Claudine ; Couch, Fergus ; Manoukian, Siranoush ; Cybulski, Cezary ; Gronwald, Jacek ; Byrski, Tomasz ; Panchal, Seema ; Nanda, Sonia ; Metcalfe, Kelly ; Rosen, Barry ; Randall, Susan ; Valentini, Adriana ; Llacuachaqui, Marcia ; Ragone, Alejandra ; Ng, Jennifer ; Buono, Kristi De ; Bisnaire, Kate ; Nikitina, Dina ; Loo, Anneli ; Khorram, Bita ; Gordon, Dina ; May, Courtney ; Jones, Michelle ; Lozano, Jose Miguel ; Kotsopoulos, Joanne ; Eng, Charis ; Sondra, J. ; Hardis, Stephen R. ; Neuhausen, Susan L. ; Narod, Steven. / Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. In: Breast Cancer Research. 2012 ; Vol. 14, No. 2.
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abstract = "Introduction: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers.Methods: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Results: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32{\%} reduction in risk (OR = 0.68; 95{\%} CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95{\%} CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95{\%} CI 0.53 to 1.31; P = 0.43).Conclusions: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.",
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T1 - Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

AU - Kotsopoulos, Joanne

AU - Lubinski, Jan

AU - Salmena, Leonardo

AU - Lynch, Henry T.

AU - Kim-Sing, Charmaine

AU - Foulkes, William D.

AU - Ghadirian, Parviz

AU - Neuhausen, Susan L.

AU - Demsky, Rochelle

AU - Tung, Nadine

AU - Ainsworth, Peter

AU - Senter, Leigha

AU - Eisen, Andrea

AU - Eng, Charis

AU - Singer, Christian

AU - Ginsburg, Ophira

AU - Blum, Joanne

AU - Huzarski, Tomasz

AU - Poll, Aletta

AU - Sun, Ping

AU - Narod, Steven A.

AU - Daly, Mary

AU - Gilchrist, Dawna

AU - Fallen, Taya

AU - Chudley, Albert

AU - Lunn, John

AU - Donenberg, Talia

AU - Karlan, Beth

AU - Kurz, Raluca N.

AU - Weitzel, Jeffrey

AU - Saal, Howard

AU - Zakalik, Dana

AU - Friedman, Susan

AU - Garber, Judy

AU - Rennert, Gad

AU - Sweet, Kevin

AU - Gershoni-Baruch, Ruth

AU - Rappaport, Christine

AU - Lemire, Edmond

AU - Stoppa-Lyonnet, Dominique

AU - Olopade, Olufunmilayo I.

AU - Merajver, Sofia

AU - Bordeleau, Louise

AU - Cullinane, Carey A.

AU - Friedman, Eitan

AU - McKinnon, Wendy

AU - Wood, Marie

AU - Rayson, Daniel

AU - Meschino, Wendy

AU - McLennan, Jane

AU - Costalas, Josephine Wagner

AU - Reilly, Robert E.

AU - Pal, Tuya

AU - Vadaparampil, Susan

AU - Offit, Kenneth

AU - Robson, Mark

AU - Kauff, Noah

AU - Klijn, Jan

AU - Moller, Pal

AU - Euhus, David M

AU - Kwong, Ava

AU - Isaacs, Claudine

AU - Couch, Fergus

AU - Manoukian, Siranoush

AU - Cybulski, Cezary

AU - Gronwald, Jacek

AU - Byrski, Tomasz

AU - Panchal, Seema

AU - Nanda, Sonia

AU - Metcalfe, Kelly

AU - Rosen, Barry

AU - Randall, Susan

AU - Valentini, Adriana

AU - Llacuachaqui, Marcia

AU - Ragone, Alejandra

AU - Ng, Jennifer

AU - Buono, Kristi De

AU - Bisnaire, Kate

AU - Nikitina, Dina

AU - Loo, Anneli

AU - Khorram, Bita

AU - Gordon, Dina

AU - May, Courtney

AU - Jones, Michelle

AU - Lozano, Jose Miguel

AU - Kotsopoulos, Joanne

AU - Eng, Charis

AU - Sondra, J.

AU - Hardis, Stephen R.

AU - Neuhausen, Susan L.

AU - Narod, Steven

PY - 2012/3/9

Y1 - 2012/3/9

N2 - Introduction: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers.Methods: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Results: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43).Conclusions: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.

AB - Introduction: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers.Methods: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Results: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43).Conclusions: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.

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U2 - 10.1186/bcr3138

DO - 10.1186/bcr3138

M3 - Article

C2 - 22405187

AN - SCOPUS:84859340313

VL - 14

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

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