Breast mri for diagnosis and staging of breast cancer

Riham H. El Khouli, Michael Jacobs, Katarzyna Macura

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Breast magnetic resonance imaging (MRI) has been a very fast developing tool for the assessment of breast cancer and quickly moved from research to clinical settings. It is being used to evaluate patients with specific indications and as a screening tool for high-risk patients. The value of breast MRI arises from its very high sensitivity in detecting breast cancer but more importantly from its ability to functionally assess physiological and biochemical properties of breast tissue, thus helping in the management of breast cancer, including the assessment of the extent of disease, the detection of contralateral disease, and the evaluation of treatment response. Response to treatment has been traditionally assessed based on gross tumor size change, a parameter that has been shown to have limitations in the accurate prediction of the treatment response and outcome. MRI offers functional methods to aid treatment response assessment that better reflect the viability of tumor and tumor burden versus just size changes. Understanding the indications for breast MRI, diagnostic criteria utilized to detect and characterize breast cancer, and technical challenges are important in both clinical and research settings. In this chapter we discuss the utilization of breast MRI in breast cancer diagnosis and staging, including the review of patterns of enhancement and principles of pharmacokinetic modeling for dynamic contrast-enhanced MRI, application of diffusion-weighted imaging and MR-guided breast biopsy, as well as review of technical considerations for optimization of image acquisition and assessment of treatment response.

Original languageEnglish (US)
Title of host publicationBreast Cancer Screening and Diagnosis: A Synopsis
PublisherSpringer New York
Pages181-200
Number of pages20
ISBN (Print)9781493912674, 9781493912667
DOIs
StatePublished - Jan 1 2015

Fingerprint

Magnetic resonance
Breast
Breast Neoplasms
Imaging techniques
Magnetic Resonance Imaging
Tumors
Diffusion Magnetic Resonance Imaging
Pharmacokinetics
Biopsy
Neoplasm Staging
Image acquisition
Therapeutics
Tumor Burden
Research
Neoplasms
Screening
Tissue

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

El Khouli, R. H., Jacobs, M., & Macura, K. (2015). Breast mri for diagnosis and staging of breast cancer. In Breast Cancer Screening and Diagnosis: A Synopsis (pp. 181-200). Springer New York. https://doi.org/10.1007/978-1-4939-1267-4_9

Breast mri for diagnosis and staging of breast cancer. / El Khouli, Riham H.; Jacobs, Michael; Macura, Katarzyna.

Breast Cancer Screening and Diagnosis: A Synopsis. Springer New York, 2015. p. 181-200.

Research output: Chapter in Book/Report/Conference proceedingChapter

El Khouli, RH, Jacobs, M & Macura, K 2015, Breast mri for diagnosis and staging of breast cancer. in Breast Cancer Screening and Diagnosis: A Synopsis. Springer New York, pp. 181-200. https://doi.org/10.1007/978-1-4939-1267-4_9
El Khouli RH, Jacobs M, Macura K. Breast mri for diagnosis and staging of breast cancer. In Breast Cancer Screening and Diagnosis: A Synopsis. Springer New York. 2015. p. 181-200 https://doi.org/10.1007/978-1-4939-1267-4_9
El Khouli, Riham H. ; Jacobs, Michael ; Macura, Katarzyna. / Breast mri for diagnosis and staging of breast cancer. Breast Cancer Screening and Diagnosis: A Synopsis. Springer New York, 2015. pp. 181-200
@inbook{ba7796835bf84e0aa5fc92c22a8fffaa,
title = "Breast mri for diagnosis and staging of breast cancer",
abstract = "Breast magnetic resonance imaging (MRI) has been a very fast developing tool for the assessment of breast cancer and quickly moved from research to clinical settings. It is being used to evaluate patients with specific indications and as a screening tool for high-risk patients. The value of breast MRI arises from its very high sensitivity in detecting breast cancer but more importantly from its ability to functionally assess physiological and biochemical properties of breast tissue, thus helping in the management of breast cancer, including the assessment of the extent of disease, the detection of contralateral disease, and the evaluation of treatment response. Response to treatment has been traditionally assessed based on gross tumor size change, a parameter that has been shown to have limitations in the accurate prediction of the treatment response and outcome. MRI offers functional methods to aid treatment response assessment that better reflect the viability of tumor and tumor burden versus just size changes. Understanding the indications for breast MRI, diagnostic criteria utilized to detect and characterize breast cancer, and technical challenges are important in both clinical and research settings. In this chapter we discuss the utilization of breast MRI in breast cancer diagnosis and staging, including the review of patterns of enhancement and principles of pharmacokinetic modeling for dynamic contrast-enhanced MRI, application of diffusion-weighted imaging and MR-guided breast biopsy, as well as review of technical considerations for optimization of image acquisition and assessment of treatment response.",
author = "{El Khouli}, {Riham H.} and Michael Jacobs and Katarzyna Macura",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-1-4939-1267-4_9",
language = "English (US)",
isbn = "9781493912674",
pages = "181--200",
booktitle = "Breast Cancer Screening and Diagnosis: A Synopsis",
publisher = "Springer New York",

}

TY - CHAP

T1 - Breast mri for diagnosis and staging of breast cancer

AU - El Khouli, Riham H.

AU - Jacobs, Michael

AU - Macura, Katarzyna

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Breast magnetic resonance imaging (MRI) has been a very fast developing tool for the assessment of breast cancer and quickly moved from research to clinical settings. It is being used to evaluate patients with specific indications and as a screening tool for high-risk patients. The value of breast MRI arises from its very high sensitivity in detecting breast cancer but more importantly from its ability to functionally assess physiological and biochemical properties of breast tissue, thus helping in the management of breast cancer, including the assessment of the extent of disease, the detection of contralateral disease, and the evaluation of treatment response. Response to treatment has been traditionally assessed based on gross tumor size change, a parameter that has been shown to have limitations in the accurate prediction of the treatment response and outcome. MRI offers functional methods to aid treatment response assessment that better reflect the viability of tumor and tumor burden versus just size changes. Understanding the indications for breast MRI, diagnostic criteria utilized to detect and characterize breast cancer, and technical challenges are important in both clinical and research settings. In this chapter we discuss the utilization of breast MRI in breast cancer diagnosis and staging, including the review of patterns of enhancement and principles of pharmacokinetic modeling for dynamic contrast-enhanced MRI, application of diffusion-weighted imaging and MR-guided breast biopsy, as well as review of technical considerations for optimization of image acquisition and assessment of treatment response.

AB - Breast magnetic resonance imaging (MRI) has been a very fast developing tool for the assessment of breast cancer and quickly moved from research to clinical settings. It is being used to evaluate patients with specific indications and as a screening tool for high-risk patients. The value of breast MRI arises from its very high sensitivity in detecting breast cancer but more importantly from its ability to functionally assess physiological and biochemical properties of breast tissue, thus helping in the management of breast cancer, including the assessment of the extent of disease, the detection of contralateral disease, and the evaluation of treatment response. Response to treatment has been traditionally assessed based on gross tumor size change, a parameter that has been shown to have limitations in the accurate prediction of the treatment response and outcome. MRI offers functional methods to aid treatment response assessment that better reflect the viability of tumor and tumor burden versus just size changes. Understanding the indications for breast MRI, diagnostic criteria utilized to detect and characterize breast cancer, and technical challenges are important in both clinical and research settings. In this chapter we discuss the utilization of breast MRI in breast cancer diagnosis and staging, including the review of patterns of enhancement and principles of pharmacokinetic modeling for dynamic contrast-enhanced MRI, application of diffusion-weighted imaging and MR-guided breast biopsy, as well as review of technical considerations for optimization of image acquisition and assessment of treatment response.

UR - http://www.scopus.com/inward/record.url?scp=84944104791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944104791&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-1267-4_9

DO - 10.1007/978-1-4939-1267-4_9

M3 - Chapter

AN - SCOPUS:84944104791

SN - 9781493912674

SN - 9781493912667

SP - 181

EP - 200

BT - Breast Cancer Screening and Diagnosis: A Synopsis

PB - Springer New York

ER -