Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi

Barbara Dancheck, Veronique Nussenblatt, Michelle O. Ricks, Newton Kumwenda, Margaret C. Neville, Dana T. Moncrief, Taha E Taha, Richard David Semba

Research output: Contribution to journalArticle

Abstract

The acute phase response and inflammation are associated with lower plasma retinol concentrations, but their effect on breast milk retinol concentrations is unclear. We measured plasma retinol concentrations, acute phase proteins, and breast milk retinol concentrations in 237 breast-feeding women at 2 wk postpartum in Blantyre, Malawi; 16.5% of the women had plasma retinol <0.70 μmol/L. and 14.8% had breast milk retinol <1.05 μmol/L. Among women with and without inflammation [α1-acid glycoprotein (AGP) > 1 g/L and/or C-reactive protein (CRP) > 5 mg/L], geometric mean (95% Cl) plasma retinol was 0.89 (0.84, 0.94) and 1.05 (1.01, 1.17) μmol/L, respectively (P <0.0001). Among women with and without inflammation, geometric mean (95% Cl) breast milk retinol was 2.12 (1.89, 2.36) and 2.05 (1.75, 2.39) μmol/L, respectively (P = 0.74). In multiple linear regression models adjusting for age, parity, education, BMI, and days postpartum, plasma retinol concentrations were associated with plasma AGP and CRP concentrations (P <0.0001 and P = 0.01, respectively), whereas breast milk retinol concentrations were unaffected by plasma AGP and CRP concentrations (P = 0.22 and P = 0.86, respectively). These findings suggest that breast milk retinol concentrations are not affected by systemic inflammation.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalJournal of Nutrition
Volume135
Issue number2
StatePublished - Feb 2005

Fingerprint

Malawi
breast feeding
Human Milk
breast milk
Breast Feeding
Vitamin A
vitamin A
inflammation
Inflammation
C-reactive protein
C-Reactive Protein
Postpartum Period
Linear Models
Acute-Phase Reaction
acute phase proteins
Acute-Phase Proteins
Parity
education
Education

Keywords

  • Acute phase response
  • Inflammation
  • Milk
  • Retinol
  • Vitamin A deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Dancheck, B., Nussenblatt, V., Ricks, M. O., Kumwenda, N., Neville, M. C., Moncrief, D. T., ... Semba, R. D. (2005). Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi. Journal of Nutrition, 135(2), 223-226.

Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi. / Dancheck, Barbara; Nussenblatt, Veronique; Ricks, Michelle O.; Kumwenda, Newton; Neville, Margaret C.; Moncrief, Dana T.; Taha, Taha E; Semba, Richard David.

In: Journal of Nutrition, Vol. 135, No. 2, 02.2005, p. 223-226.

Research output: Contribution to journalArticle

Dancheck, B, Nussenblatt, V, Ricks, MO, Kumwenda, N, Neville, MC, Moncrief, DT, Taha, TE & Semba, RD 2005, 'Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi', Journal of Nutrition, vol. 135, no. 2, pp. 223-226.
Dancheck B, Nussenblatt V, Ricks MO, Kumwenda N, Neville MC, Moncrief DT et al. Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi. Journal of Nutrition. 2005 Feb;135(2):223-226.
Dancheck, Barbara ; Nussenblatt, Veronique ; Ricks, Michelle O. ; Kumwenda, Newton ; Neville, Margaret C. ; Moncrief, Dana T. ; Taha, Taha E ; Semba, Richard David. / Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi. In: Journal of Nutrition. 2005 ; Vol. 135, No. 2. pp. 223-226.
@article{a97551d605b8406db60c77580d4d7afe,
title = "Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi",
abstract = "The acute phase response and inflammation are associated with lower plasma retinol concentrations, but their effect on breast milk retinol concentrations is unclear. We measured plasma retinol concentrations, acute phase proteins, and breast milk retinol concentrations in 237 breast-feeding women at 2 wk postpartum in Blantyre, Malawi; 16.5{\%} of the women had plasma retinol <0.70 μmol/L. and 14.8{\%} had breast milk retinol <1.05 μmol/L. Among women with and without inflammation [α1-acid glycoprotein (AGP) > 1 g/L and/or C-reactive protein (CRP) > 5 mg/L], geometric mean (95{\%} Cl) plasma retinol was 0.89 (0.84, 0.94) and 1.05 (1.01, 1.17) μmol/L, respectively (P <0.0001). Among women with and without inflammation, geometric mean (95{\%} Cl) breast milk retinol was 2.12 (1.89, 2.36) and 2.05 (1.75, 2.39) μmol/L, respectively (P = 0.74). In multiple linear regression models adjusting for age, parity, education, BMI, and days postpartum, plasma retinol concentrations were associated with plasma AGP and CRP concentrations (P <0.0001 and P = 0.01, respectively), whereas breast milk retinol concentrations were unaffected by plasma AGP and CRP concentrations (P = 0.22 and P = 0.86, respectively). These findings suggest that breast milk retinol concentrations are not affected by systemic inflammation.",
keywords = "Acute phase response, Inflammation, Milk, Retinol, Vitamin A deficiency",
author = "Barbara Dancheck and Veronique Nussenblatt and Ricks, {Michelle O.} and Newton Kumwenda and Neville, {Margaret C.} and Moncrief, {Dana T.} and Taha, {Taha E} and Semba, {Richard David}",
year = "2005",
month = "2",
language = "English (US)",
volume = "135",
pages = "223--226",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "2",

}

TY - JOUR

T1 - Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi

AU - Dancheck, Barbara

AU - Nussenblatt, Veronique

AU - Ricks, Michelle O.

AU - Kumwenda, Newton

AU - Neville, Margaret C.

AU - Moncrief, Dana T.

AU - Taha, Taha E

AU - Semba, Richard David

PY - 2005/2

Y1 - 2005/2

N2 - The acute phase response and inflammation are associated with lower plasma retinol concentrations, but their effect on breast milk retinol concentrations is unclear. We measured plasma retinol concentrations, acute phase proteins, and breast milk retinol concentrations in 237 breast-feeding women at 2 wk postpartum in Blantyre, Malawi; 16.5% of the women had plasma retinol <0.70 μmol/L. and 14.8% had breast milk retinol <1.05 μmol/L. Among women with and without inflammation [α1-acid glycoprotein (AGP) > 1 g/L and/or C-reactive protein (CRP) > 5 mg/L], geometric mean (95% Cl) plasma retinol was 0.89 (0.84, 0.94) and 1.05 (1.01, 1.17) μmol/L, respectively (P <0.0001). Among women with and without inflammation, geometric mean (95% Cl) breast milk retinol was 2.12 (1.89, 2.36) and 2.05 (1.75, 2.39) μmol/L, respectively (P = 0.74). In multiple linear regression models adjusting for age, parity, education, BMI, and days postpartum, plasma retinol concentrations were associated with plasma AGP and CRP concentrations (P <0.0001 and P = 0.01, respectively), whereas breast milk retinol concentrations were unaffected by plasma AGP and CRP concentrations (P = 0.22 and P = 0.86, respectively). These findings suggest that breast milk retinol concentrations are not affected by systemic inflammation.

AB - The acute phase response and inflammation are associated with lower plasma retinol concentrations, but their effect on breast milk retinol concentrations is unclear. We measured plasma retinol concentrations, acute phase proteins, and breast milk retinol concentrations in 237 breast-feeding women at 2 wk postpartum in Blantyre, Malawi; 16.5% of the women had plasma retinol <0.70 μmol/L. and 14.8% had breast milk retinol <1.05 μmol/L. Among women with and without inflammation [α1-acid glycoprotein (AGP) > 1 g/L and/or C-reactive protein (CRP) > 5 mg/L], geometric mean (95% Cl) plasma retinol was 0.89 (0.84, 0.94) and 1.05 (1.01, 1.17) μmol/L, respectively (P <0.0001). Among women with and without inflammation, geometric mean (95% Cl) breast milk retinol was 2.12 (1.89, 2.36) and 2.05 (1.75, 2.39) μmol/L, respectively (P = 0.74). In multiple linear regression models adjusting for age, parity, education, BMI, and days postpartum, plasma retinol concentrations were associated with plasma AGP and CRP concentrations (P <0.0001 and P = 0.01, respectively), whereas breast milk retinol concentrations were unaffected by plasma AGP and CRP concentrations (P = 0.22 and P = 0.86, respectively). These findings suggest that breast milk retinol concentrations are not affected by systemic inflammation.

KW - Acute phase response

KW - Inflammation

KW - Milk

KW - Retinol

KW - Vitamin A deficiency

UR - http://www.scopus.com/inward/record.url?scp=13244279399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13244279399&partnerID=8YFLogxK

M3 - Article

C2 - 15671217

AN - SCOPUS:13244279399

VL - 135

SP - 223

EP - 226

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 2

ER -