Breast cancer susceptibility polymorphisms and endometrial cancer risk: A collaborative endometrial cancer study

Catherine S. Healey, Shahana Ahmed, P. Webb, J. Young, L. McQuire, S. Baron-Hay, D. Bell, A. Bonaventura, A. Brand, S. Braye, J. Carter, F. Chan, C. Dalrymple, A. Ferrier, G. Gard, N. Hacker, R. Hogg, R. Houghton, D. Marsden, K. McIlroyG. Otton, S. Pather, A. Proietto, G. Robertson, J. Scurry, R. Sharma, G. Wain, F. Wong, J. Armes, A. Crandon, M. Cummings, R. Land, J. Nicklin, L. Perrin, A. Obermair, B. Ward, M. Davy, T. Dodd, J. Miller, M. Oehler, S. Paramasivum, J. Pierides, F. Whitehead, P. Blomfield, D. Challis, D. Neesham, J. Pyman, M. Quinn, R. Rome, M. Weitzer, B. Brennan, I. Hammond, Y. Leung, A. McCartney, C. Stewart, J. Thompson, S. O'Brien, S. Moore, K. Ferguson, M. Walsh, R. Cicero, L. Green, J. Griffith, L. Jackman, B. Ranieri, M. O'Brien, P. Schultz, B. Alexander, C. Baxter, H. Croy, A. Fitzgerald, E. Herron, C. Hill, M. Jones, J. Maidens, A. Marshall, K. Martin, J. Mayhew, E. Minehan, D. Roffe, H. Shirley, H. Steane, A. Stenlake, A. Ward, S. Webb, J. White, Tracy A. O'Mara, Kaltin Ferguson, Diether Lambrechts, Diego A. Garcia-Dios, Ignace Vergote, Frederic Amant, Ian Tomlinson, M. Adams, A. Al-Samarraie, S. Anwar, R. Athavale, S. Awad, A. Bali, A. Barnes, G. Cawdell, S. Chan, K. Chin, P. Cornes, M. Crawford, J. Cullimore, S. Ghaem-Maghami, R. Gornall, J. Green, M. Hall, M. Harvey, J. Hawe, A. Head, J. Herod, M. Hingorani, M. Hocking, C. Holland, T. Hollingsworth, J. Hollingworth, T. Ind, R. Irvine, C. Irwin, M. Katesmark, S. Kehoe, G. Kheng-Chew, K. Lankester, A. Linder, D. Luesley, C. BLynch, V. McFarlane, R. Naik, N. Nicholas, D. Nugent, S. Oates, A. Oladipo, A. Papadopoulos, S. Pearson, D. Radstone, S. Raju, A. Rathmell, C. Redman, M. Rymer, P. Sarhanis, G. Sparrow, N. Stuart, S. Sundar, A. Thompson, S. Tinkler, S. Trent, A. Tristram, N. Walji, R. Woolas, Kimberley Howarth, Maggie Gorman, Shirley Hodgson, Ian Tomlinson, Hannah P. Yang, Jolanta Lissowska, Louise A. Brinton, Stephen Chanock, Montserrat Garcia-Closas, Per Hall, Jianjun Liu, Mitul Shah, Paul D.P. Pharoah, Deborah J. Thompson, Timothy R. Rebbeck, Brian L. Strom, Alison M. Dunning, Douglas F. Easton, Amanda B. Spurdle

Research output: Contribution to journalArticle

Abstract

Recent large-scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11 928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.

Original languageEnglish (US)
Article numberbgr214
Pages (from-to)1862-1866
Number of pages5
JournalCarcinogenesis
Volume32
Issue number12
DOIs
StatePublished - Dec 1 2011

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ASJC Scopus subject areas

  • Cancer Research

Cite this

Healey, C. S., Ahmed, S., Webb, P., Young, J., McQuire, L., Baron-Hay, S., Bell, D., Bonaventura, A., Brand, A., Braye, S., Carter, J., Chan, F., Dalrymple, C., Ferrier, A., Gard, G., Hacker, N., Hogg, R., Houghton, R., Marsden, D., ... Spurdle, A. B. (2011). Breast cancer susceptibility polymorphisms and endometrial cancer risk: A collaborative endometrial cancer study. Carcinogenesis, 32(12), 1862-1866. [bgr214]. https://doi.org/10.1093/carcin/bgr214