Breast cancer metabolism

Jessica Tan, Quy Hoa Le Thi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aberrant metabolic pathways present in breast cancer contribute to breast cancer heterogeneity.Differences in glycolytic upregulation among breast cancer subtypes can be attributed to GLUT expression.Choline metabolism in breast cancer is strongly associated with tumor grades. Different roles of estrogen in estrogen metabolism and ER binding promote breast cancer tumorigenicity.Metabolic profiling of breast cancers can be used for clinical breast cancer diagnosis and prediction of recurrence or metastasis.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages83-93
Number of pages11
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1063
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Breast cancer
  • Choline metabolism
  • Estrogen metabolism
  • Estrogen receptor status
  • Glycolytic upregulation
  • Metabolic fingerprint
  • Serine biosynthesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Tan, J., & Le Thi, Q. H. (2018). Breast cancer metabolism. In Advances in Experimental Medicine and Biology (pp. 83-93). (Advances in Experimental Medicine and Biology; Vol. 1063). Springer New York LLC. https://doi.org/10.1007/978-3-319-77736-8_6