@article{8ded4066792b47c39462b20fa65830a0,
title = "Breast cancer incidence in women with a history of progesterone deficiency",
abstract = "In order to investigate the nature of the association of involuntarily delayed first birth and risk of breast cancer, 1083 white women who had been evaluated and treated for infertility from 1945-1965 were followed prospectively through April 1978 to ascertain their breast cancer incidence. These women were categorized as to the cause of infertility into two groups, those with endogenous progesterone deficiency (PD) and those with nonhormonal causes (NH). Women in the PD group had 5.4 times the risk of premenopausal breast cancer compared to women in the NH group. This excess risk could not be explained by differences between the two groups in ages at menarche or menopause, history of oral contraceptive use, history of benign breast dis ease or age at first birth. Women in the PD group also experienced a 10-fold increase in deaths from all malignant neopiasms compared to the NH group. The Incidence of postmenopausal breast cancer did not differ significantly between the two groups.",
keywords = "Breast neoplasms, Fertility, Progesterone",
author = "Cowan, {Linda D.} and Leon Gordis and Tonascia, {James A.} and Jones, {Georgeanna Seegar}",
note = "Funding Information: Received for publication November 6, 1980, and in final form February 17, 1981. Abbreviations: NH, nonhormonal group; PD, progesterone-deficient group. ' Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD. Reprint requests to Dr. Cowan at current address: Lipid Research Clinic, Population Studies, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104. 1Department of Biostatistics, School of Hygiene and Public Health, The Johns Hopkins University. 1Department of Obstetrics and Gynecology, The Johns Hopkins School of Medicine. Present address: Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA. This work was supported by an award from the John Graham Fund and from grants 5P01 CA11489 and 5T01 CA05165 from the National Cancer Institute. The authors thank Mrs. Carol Licht, Mrs. Corrine O'Connor Bell, Miss Marie Rampolla, Dr. Anna Cardenas, Mrs. Roneca Grove and Mrs. Florence Kramer for their assistance in data collection.",
year = "1981",
month = aug,
doi = "10.1093/oxfordjournals.aje.a113184",
language = "English (US)",
volume = "114",
pages = "209--217",
journal = "American journal of epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "2",
}