BRCA1: Linking HOX to breast cancer suppression

Kideok Jin, Saraswati Sukumar

Research output: Contribution to journalArticle

Abstract

Homeobox (HOX) genes play key roles in embryogenesis and tissue differentiation. Recently, a number of groups have reported altered HOX gene expression in breast cancer. However, the mechanism of HOX gene regulation and the search for direct targets of its transcriptional regulatory function have been minimally fruitful. Recently, Gilbert and colleagues reported that HOXA9 restrains breast cancer progression by upregulation of BRCA1, a tumor suppressor. This finding raises our hope that more, rather elusive targets of HOX genes important in tumor progression or suppression will be found in the future.

Original languageEnglish (US)
Article number306
JournalBreast Cancer Research
Volume12
Issue number4
DOIs
Publication statusPublished - Jul 23 2010

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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