Brazilian Longitudinal Study of Adult health (ELSA-Brasil): Objectives and design

Estela M.L. Aquino, Sandhi Maria Barreto, Isabela M. Bensenor, Marilia S. Carvalho, Dóra Chor, Bruce B. Duncan, Paulo A. Lotufo, José Geraldo Mill, Maria Del Carmen Molina, Eduardo L.A. Mota, Valéria Maria Azeredo Passos, Maria Inês Schmidt, Moyses Szklo

Research output: Contribution to journalArticle

Abstract

Although low-and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalAmerican journal of epidemiology
Volume175
Issue number4
DOIs
StatePublished - Feb 15 2012

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Keywords

  • cardiovascular diseases
  • chronic disease
  • cohort studies
  • developing countries
  • diabetes mellitus
  • epidemiologic methods
  • longitudinal studies
  • occupational health

ASJC Scopus subject areas

  • Epidemiology

Cite this

Aquino, E. M. L., Barreto, S. M., Bensenor, I. M., Carvalho, M. S., Chor, D., Duncan, B. B., Lotufo, P. A., Mill, J. G., Molina, M. D. C., Mota, E. L. A., Passos, V. M. A., Schmidt, M. I., & Szklo, M. (2012). Brazilian Longitudinal Study of Adult health (ELSA-Brasil): Objectives and design. American journal of epidemiology, 175(4), 315-324. https://doi.org/10.1093/aje/kwr294