Abstract
Although low-and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 315-324 |
| Number of pages | 10 |
| Journal | American Journal of Epidemiology |
| Volume | 175 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 15 2012 |
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Keywords
- cardiovascular diseases
- chronic disease
- cohort studies
- developing countries
- diabetes mellitus
- epidemiologic methods
- longitudinal studies
- occupational health
ASJC Scopus subject areas
- Epidemiology
Cite this
Brazilian Longitudinal Study of Adult health (ELSA-Brasil) : Objectives and design. / Aquino, Estela M L; Barreto, Sandhi Maria; Bensenor, Isabela M.; Carvalho, Marilia S.; Chor, Dóra; Duncan, Bruce B.; Lotufo, Paulo A.; Mill, José Geraldo; Molina, Maria Del Carmen; Mota, Eduardo L A; Passos, Valéria Maria Azeredo; Schmidt, Maria Inês; Szklo, Moyses.
In: American Journal of Epidemiology, Vol. 175, No. 4, 15.02.2012, p. 315-324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brazilian Longitudinal Study of Adult health (ELSA-Brasil)
T2 - Objectives and design
AU - Aquino, Estela M L
AU - Barreto, Sandhi Maria
AU - Bensenor, Isabela M.
AU - Carvalho, Marilia S.
AU - Chor, Dóra
AU - Duncan, Bruce B.
AU - Lotufo, Paulo A.
AU - Mill, José Geraldo
AU - Molina, Maria Del Carmen
AU - Mota, Eduardo L A
AU - Passos, Valéria Maria Azeredo
AU - Schmidt, Maria Inês
AU - Szklo, Moyses
PY - 2012/2/15
Y1 - 2012/2/15
N2 - Although low-and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.
AB - Although low-and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.
KW - cardiovascular diseases
KW - chronic disease
KW - cohort studies
KW - developing countries
KW - diabetes mellitus
KW - epidemiologic methods
KW - longitudinal studies
KW - occupational health
UR - http://www.scopus.com/inward/record.url?scp=84856727839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856727839&partnerID=8YFLogxK
U2 - 10.1093/aje/kwr294
DO - 10.1093/aje/kwr294
M3 - Article
VL - 175
SP - 315
EP - 324
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 4
ER -