TY - JOUR
T1 - Brazilian Aedes aegypti as a Competent Vector for Multiple Complex Arboviral Coinfections
AU - Rodrigues, Nilton Barnabé
AU - Godoy, Raquel Soares Maia
AU - Orfano, Alessandra Silva
AU - Chaves, Barbara Aparecida
AU - Campolina, Thais Bonifácio
AU - Costa, Breno Dos Anjos
AU - Félix, Luíza Dos Santos
AU - Silva, Breno Melo
AU - Norris, Douglas Eric
AU - Pimenta, Paulo Filemon Paolucci
AU - Secundino, Nagila Francinete Costa
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Background: Aedes aegypti is a highly competent vector in the transmission of arboviruses, such as chikungunya, dengue, Zika, and yellow fever viruses, and causes single and coinfections in the populations of tropical countries. Methods: The infection rate, viral abundance (VA), vector competence (VC), disseminated infection, and survival rate were recorded after single and multiple infections of the vector with 15 combinations of chikungunya, dengue, Zika, and yellow fever arboviruses. Results: Infection rates were 100% in all single and multiple infection experiments, except in 1 triple coinfection that presented a rate of 50%. The VC and disseminated infection rate varied from 100% (in single and quadruple infections) to 40% (in dual and triple infections). The dual and triple coinfections altered the VC and/or VA of ≥1 arbovirus. The highest viral VAs were detected for a single infection with chikungunya. The VAs in quadruple infections were similar when compared with each respective single infection. A decrease in survival rates was observed in a few combinations. Conclusions: A. aegypti was able to host all single and multiple arboviral coinfections. The interference of the chikungunya virus suggests that distinct arbovirus families may have a significant role in complex coinfections.
AB - Background: Aedes aegypti is a highly competent vector in the transmission of arboviruses, such as chikungunya, dengue, Zika, and yellow fever viruses, and causes single and coinfections in the populations of tropical countries. Methods: The infection rate, viral abundance (VA), vector competence (VC), disseminated infection, and survival rate were recorded after single and multiple infections of the vector with 15 combinations of chikungunya, dengue, Zika, and yellow fever arboviruses. Results: Infection rates were 100% in all single and multiple infection experiments, except in 1 triple coinfection that presented a rate of 50%. The VC and disseminated infection rate varied from 100% (in single and quadruple infections) to 40% (in dual and triple infections). The dual and triple coinfections altered the VC and/or VA of ≥1 arbovirus. The highest viral VAs were detected for a single infection with chikungunya. The VAs in quadruple infections were similar when compared with each respective single infection. A decrease in survival rates was observed in a few combinations. Conclusions: A. aegypti was able to host all single and multiple arboviral coinfections. The interference of the chikungunya virus suggests that distinct arbovirus families may have a significant role in complex coinfections.
KW - Aedes aegypti
KW - Zika virus
KW - chikungunya virus
KW - coinfection
KW - dengue virus
KW - yellow fever virus
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U2 - 10.1093/infdis/jiab066
DO - 10.1093/infdis/jiab066
M3 - Article
C2 - 33544850
AN - SCOPUS:85110354289
SN - 0022-1899
VL - 224
SP - 101
EP - 108
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -