Branched‐chain ketoacids reduce muscle protein degradation in duchenne muscular dystrophy

Peter M. Stewart, Mackenzie Walser, Daniel B. Drachman

Research output: Contribution to journalArticle

Abstract

In order to determine whether branched‐chain ketoacids can reduce the excessive rate of muscle protein degradation that characterizes Duchenne muscular dystrophy, nine boys affected with the disease were studied in a metabolic ward while receiving meat‐free diets. After a three‐day equilibration period, excretion rates of 3‐methylhistidine and creatinine were measured in two consecutive four‐day periods. In the second period, a supplement containing a mixture of ornithine α‐ketoisocaproate, α‐ketoisovalerate, and α‐keto‐β‐methylvalerate in a proportion of 4 : 1 : 1 was administered orally at a dosage of 0.45 gm/kg/day. During treatment with the ketoacids, 3‐methylhistidine excretion fell by a small (mean: 14%) but highly significant (P < 0.01) extent, whether expressed in absolute terms or in relation to creatinine excretion. No adverse effects were noted. We conclude that this mixture of ketoacids acutely reduces muscle protein degradation in patients with Duchenne muscular dystrophy.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalMuscle & nerve
Volume5
Issue number3
DOIs
StatePublished - Mar 1982

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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