Brainstem branches from olivocochlear axons in cats and rodents

M. C. Brown, M. C. Liberman, T. E. Benson, David Kay Ryugo

Research output: Contribution to journalArticle

Abstract

Horseradish peroxidase was used to label axons of olivocochlear (OC) neurons by intracellular injections in cats and extracellular injections in rodents. These axons arise from cell bodies in the superior olivary complex and project to the cochlea. En route to the cochlea, the thick axons (> 0.7 μm diam.) of medial olivocochlear (MOC) neurons formed collaterals that terminated in the ventral cochlear nucleus, the interstitial nucleus of the vestibular nerve (in cats), and the inferior vestibular nucleus (in rodents). The thin axons (<0.7 μm diam.), presumed to arise from lateral olivocochlear (LOC) neurons, did not branch near the CN. Within the CN, the MOC collaterals tended to ramify in and near regions with high densities of granule cells, regions also associated with the terminals of type II afferent axons (Brown et al.: J. Comp. Neurol. 278:581-590, '88). These results suggest that those fibers associated peripherally with outer hair cells (MOC efferents and type II afferents) are associated centrally with regions containing granule cells, whereas those fibers associated with inner hair cells peripherally (LOC efferents and type I afferents) are not.

Original languageEnglish (US)
Pages (from-to)591-603
Number of pages13
JournalJournal of Comparative Neurology
Volume278
Issue number4
StatePublished - 1988

Fingerprint

Brain Stem
Axons
Rodentia
Cats
Cochlea
Outer Auditory Hair Cells
Neurons
Inner Auditory Hair Cells
Vestibular Nerve
Vestibular Nuclei
Cochlear Nucleus
Injections
Horseradish Peroxidase
Cell Count

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brown, M. C., Liberman, M. C., Benson, T. E., & Ryugo, D. K. (1988). Brainstem branches from olivocochlear axons in cats and rodents. Journal of Comparative Neurology, 278(4), 591-603.

Brainstem branches from olivocochlear axons in cats and rodents. / Brown, M. C.; Liberman, M. C.; Benson, T. E.; Ryugo, David Kay.

In: Journal of Comparative Neurology, Vol. 278, No. 4, 1988, p. 591-603.

Research output: Contribution to journalArticle

Brown, MC, Liberman, MC, Benson, TE & Ryugo, DK 1988, 'Brainstem branches from olivocochlear axons in cats and rodents', Journal of Comparative Neurology, vol. 278, no. 4, pp. 591-603.
Brown, M. C. ; Liberman, M. C. ; Benson, T. E. ; Ryugo, David Kay. / Brainstem branches from olivocochlear axons in cats and rodents. In: Journal of Comparative Neurology. 1988 ; Vol. 278, No. 4. pp. 591-603.
@article{81d82d9ce0db4ff3af38a158b6b38852,
title = "Brainstem branches from olivocochlear axons in cats and rodents",
abstract = "Horseradish peroxidase was used to label axons of olivocochlear (OC) neurons by intracellular injections in cats and extracellular injections in rodents. These axons arise from cell bodies in the superior olivary complex and project to the cochlea. En route to the cochlea, the thick axons (> 0.7 μm diam.) of medial olivocochlear (MOC) neurons formed collaterals that terminated in the ventral cochlear nucleus, the interstitial nucleus of the vestibular nerve (in cats), and the inferior vestibular nucleus (in rodents). The thin axons (<0.7 μm diam.), presumed to arise from lateral olivocochlear (LOC) neurons, did not branch near the CN. Within the CN, the MOC collaterals tended to ramify in and near regions with high densities of granule cells, regions also associated with the terminals of type II afferent axons (Brown et al.: J. Comp. Neurol. 278:581-590, '88). These results suggest that those fibers associated peripherally with outer hair cells (MOC efferents and type II afferents) are associated centrally with regions containing granule cells, whereas those fibers associated with inner hair cells peripherally (LOC efferents and type I afferents) are not.",
author = "Brown, {M. C.} and Liberman, {M. C.} and Benson, {T. E.} and Ryugo, {David Kay}",
year = "1988",
language = "English (US)",
volume = "278",
pages = "591--603",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Brainstem branches from olivocochlear axons in cats and rodents

AU - Brown, M. C.

AU - Liberman, M. C.

AU - Benson, T. E.

AU - Ryugo, David Kay

PY - 1988

Y1 - 1988

N2 - Horseradish peroxidase was used to label axons of olivocochlear (OC) neurons by intracellular injections in cats and extracellular injections in rodents. These axons arise from cell bodies in the superior olivary complex and project to the cochlea. En route to the cochlea, the thick axons (> 0.7 μm diam.) of medial olivocochlear (MOC) neurons formed collaterals that terminated in the ventral cochlear nucleus, the interstitial nucleus of the vestibular nerve (in cats), and the inferior vestibular nucleus (in rodents). The thin axons (<0.7 μm diam.), presumed to arise from lateral olivocochlear (LOC) neurons, did not branch near the CN. Within the CN, the MOC collaterals tended to ramify in and near regions with high densities of granule cells, regions also associated with the terminals of type II afferent axons (Brown et al.: J. Comp. Neurol. 278:581-590, '88). These results suggest that those fibers associated peripherally with outer hair cells (MOC efferents and type II afferents) are associated centrally with regions containing granule cells, whereas those fibers associated with inner hair cells peripherally (LOC efferents and type I afferents) are not.

AB - Horseradish peroxidase was used to label axons of olivocochlear (OC) neurons by intracellular injections in cats and extracellular injections in rodents. These axons arise from cell bodies in the superior olivary complex and project to the cochlea. En route to the cochlea, the thick axons (> 0.7 μm diam.) of medial olivocochlear (MOC) neurons formed collaterals that terminated in the ventral cochlear nucleus, the interstitial nucleus of the vestibular nerve (in cats), and the inferior vestibular nucleus (in rodents). The thin axons (<0.7 μm diam.), presumed to arise from lateral olivocochlear (LOC) neurons, did not branch near the CN. Within the CN, the MOC collaterals tended to ramify in and near regions with high densities of granule cells, regions also associated with the terminals of type II afferent axons (Brown et al.: J. Comp. Neurol. 278:581-590, '88). These results suggest that those fibers associated peripherally with outer hair cells (MOC efferents and type II afferents) are associated centrally with regions containing granule cells, whereas those fibers associated with inner hair cells peripherally (LOC efferents and type I afferents) are not.

UR - http://www.scopus.com/inward/record.url?scp=0024205688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024205688&partnerID=8YFLogxK

M3 - Article

C2 - 3230172

AN - SCOPUS:0024205688

VL - 278

SP - 591

EP - 603

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 4

ER -