Brain uptake and utilization of fatty acids: Applications to peroxisomal biogenesis diseases

P. A. Watkins, J. A. Hamilton, A. Leaf, A. A. Spector, S. A. Moore, R. E. Anderson, H. W. Moser, M. J. Noetzel, R. Katz

Research output: Contribution to journalArticlepeer-review

Abstract

The brain is rich in diverse fatty acids saturated, monounsaturated and polyunsaturated fatty acids with chain lengths ranging from less than 16 to more than 24 carbons that make up the complex lipids present in this organ. While some fatty acids are derived from endogenous synthesis, others must come from exogenous sources. The mechanism(s) by which fatty acids enter cells has been the subject of much debate. While some investigators argue for a protein-mediated process, others suggest that simple diffusion is sufficient. In the brain, uptake is further complicated by the presence of the blood-brain barrier. Brain fatty acid homeostasis is disturbed in many human disorders, as typified by the peroxisomal biogenesis diseases. A workshop designed to bring together researchers from varied backgrounds to discuss these issues in an open forum was held in March, 2000. In addition to assessing the current state of knowledge, areas requiring additional investigation were identified and recommendations for future research were made. A brief overview of the invited talks is presented here.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalJournal of Molecular Neuroscience
Volume16
Issue number2-3
DOIs
StatePublished - 2001

Keywords

  • Brain
  • Fatty acid
  • Peroxisomal biogenesis diseases
  • Transport

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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