Brain tumors disrupt the resting-state connectome

Darian H. Hadjiabadi, Leland Pung, Jiangyang Zhang, B. D. Ward, Woo Taek Lim, Meghana Kalavar, Nitish V Thakor, Bharat B. Biswal, Arvind Pathak

Research output: Contribution to journalArticle

Abstract

Brain tumor patients often experience functional deficits that extend beyond the tumor site. While resting-state functional MRI (rsfMRI) has been used to map such functional connectivity changes in brain tumor patients, the interplay between abnormal tumor vasculature and the rsfMRI signal is still not well understood. Therefore, there is an exigent need for new tools to elucidate how the blood‑oxygenation-level-dependent (BOLD) rsfMRI signal is modulated in brain cancer. In this initial study, we explore the utility of a preclinical model for quantifying brain tumor-induced changes on the rsfMRI signal and resting-state brain connectivity. We demonstrate that brain tumors induce brain-wide alterations of resting-state networks that extend to the contralateral hemisphere, accompanied by global attenuation of the rsfMRI signal. Preliminary histology suggests that some of these alterations in brain connectivity may be attributable to tumor-related remodeling of the neurovasculature. Moreover, this work recapitulates clinical rsfMRI findings from brain tumor patients in terms of the effects of tumor size on the neurovascular microenvironment. Collectively, these results lay the foundation of a preclinical platform for exploring the usefulness of rsfMRI as a potential new biomarker in patients with brain cancer.

Original languageEnglish (US)
Pages (from-to)279-289
Number of pages11
JournalNeuroImage: Clinical
Volume18
DOIs
StatePublished - Jan 1 2018

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Connectome
Brain Neoplasms
Magnetic Resonance Imaging
Neoplasms
Brain
Histology
Biomarkers

Keywords

  • Brain tumor
  • Connectivity
  • fMRI
  • Neurovascular uncoupling
  • Resting-state

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Hadjiabadi, D. H., Pung, L., Zhang, J., Ward, B. D., Lim, W. T., Kalavar, M., ... Pathak, A. (2018). Brain tumors disrupt the resting-state connectome. NeuroImage: Clinical, 18, 279-289. https://doi.org/10.1016/j.nicl.2018.01.026

Brain tumors disrupt the resting-state connectome. / Hadjiabadi, Darian H.; Pung, Leland; Zhang, Jiangyang; Ward, B. D.; Lim, Woo Taek; Kalavar, Meghana; Thakor, Nitish V; Biswal, Bharat B.; Pathak, Arvind.

In: NeuroImage: Clinical, Vol. 18, 01.01.2018, p. 279-289.

Research output: Contribution to journalArticle

Hadjiabadi, DH, Pung, L, Zhang, J, Ward, BD, Lim, WT, Kalavar, M, Thakor, NV, Biswal, BB & Pathak, A 2018, 'Brain tumors disrupt the resting-state connectome', NeuroImage: Clinical, vol. 18, pp. 279-289. https://doi.org/10.1016/j.nicl.2018.01.026
Hadjiabadi DH, Pung L, Zhang J, Ward BD, Lim WT, Kalavar M et al. Brain tumors disrupt the resting-state connectome. NeuroImage: Clinical. 2018 Jan 1;18:279-289. https://doi.org/10.1016/j.nicl.2018.01.026
Hadjiabadi, Darian H. ; Pung, Leland ; Zhang, Jiangyang ; Ward, B. D. ; Lim, Woo Taek ; Kalavar, Meghana ; Thakor, Nitish V ; Biswal, Bharat B. ; Pathak, Arvind. / Brain tumors disrupt the resting-state connectome. In: NeuroImage: Clinical. 2018 ; Vol. 18. pp. 279-289.
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