Brain structure and function correlates of cognitive subtypes in schizophrenia

Daniel Geisler; Esther Walton; Melissa Naylor; Veit Roessner; Kelvin O. Lim; S. Charles Schulz; Randy L. Gollub; Vince D. Calhoun; Scott R. Sponheim; Stefan Ehrlich

doi:10.1016/j.pscychresns.2015.08.008

Brain structure and function correlates of cognitive subtypes in schizophrenia

Daniel Geisler, Esther Walton, Melissa Naylor, Veit Roessner, Kelvin O. Lim, S. Charles Schulz, Randy L. Gollub, Vince D. Calhoun, Scott R. Sponheim, Stefan Ehrlich

School of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Stable neuropsychological deficits may provide a reliable basis for identifying etiological subtypes of schizophrenia. The aim of this study was to identify clusters of individuals with schizophrenia based on dimensions of neuropsychological performance, and to characterize their neural correlates. We acquired neuropsychological data as well as structural and functional magnetic resonance imaging from 129 patients with schizophrenia and 165 healthy controls. We derived eight cognitive dimensions and subsequently applied a cluster analysis to identify possible schizophrenia subtypes. Analyses suggested the following four cognitive clusters of schizophrenia: (1) Diminished Verbal Fluency, (2) Diminished Verbal Memory and Poor Motor Control, (3) Diminished Face Memory and Slowed Processing, and (4) Diminished Intellectual Function. The clusters were characterized by a specific pattern of structural brain changes in areas such as Wernicke's area, lingual gyrus and occipital face area, and hippocampus as well as differences in working memory-elicited neural activity in several fronto-parietal brain regions. Separable measures of cognitive function appear to provide a method for deriving cognitive subtypes meaningfully related to brain structure and function. Because the present study identified brain-based neural correlates of the cognitive clusters, the proposed groups of individuals with schizophrenia have some external validity.

Original language	English (US)
Pages (from-to)	74-83
Number of pages	10
Journal	Psychiatry Research - Neuroimaging
Volume	234
Issue number	1
DOIs	https://doi.org/10.1016/j.pscychresns.2015.08.008
State	Published - Oct 30 2015

Keywords

Cluster analysis
Cognitive subtypes
Cortical thickness
Neural correlates
Neuropsychological performance
Schizophrenia
Subcortical volume
Working memory

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

Access to Document

10.1016/j.pscychresns.2015.08.008

Cite this

@article{e34daf92e7114c33a16d028086efe015,

title = "Brain structure and function correlates of cognitive subtypes in schizophrenia",

abstract = "Stable neuropsychological deficits may provide a reliable basis for identifying etiological subtypes of schizophrenia. The aim of this study was to identify clusters of individuals with schizophrenia based on dimensions of neuropsychological performance, and to characterize their neural correlates. We acquired neuropsychological data as well as structural and functional magnetic resonance imaging from 129 patients with schizophrenia and 165 healthy controls. We derived eight cognitive dimensions and subsequently applied a cluster analysis to identify possible schizophrenia subtypes. Analyses suggested the following four cognitive clusters of schizophrenia: (1) Diminished Verbal Fluency, (2) Diminished Verbal Memory and Poor Motor Control, (3) Diminished Face Memory and Slowed Processing, and (4) Diminished Intellectual Function. The clusters were characterized by a specific pattern of structural brain changes in areas such as Wernicke's area, lingual gyrus and occipital face area, and hippocampus as well as differences in working memory-elicited neural activity in several fronto-parietal brain regions. Separable measures of cognitive function appear to provide a method for deriving cognitive subtypes meaningfully related to brain structure and function. Because the present study identified brain-based neural correlates of the cognitive clusters, the proposed groups of individuals with schizophrenia have some external validity.",

keywords = "Cluster analysis, Cognitive subtypes, Cortical thickness, Neural correlates, Neuropsychological performance, Schizophrenia, Subcortical volume, Working memory",

author = "Daniel Geisler and Esther Walton and Melissa Naylor and Veit Roessner and Lim, {Kelvin O.} and {Charles Schulz}, S. and Gollub, {Randy L.} and Calhoun, {Vince D.} and Sponheim, {Scott R.} and Stefan Ehrlich",

note = "Funding Information: This work was supported by the National Institutes of Health (NIH/NCRR P41RR14075 , 1RC1MH089257 , and R01EB005846 ) (to VDC), Department of Energy ( DE-FG02-99ER62764 ), Mind Research Network , Morphometry BIRN ( 1U24, RR021382A ), Function BIRN ( U24RR021992-01 , NIH.NCRR MO1 RR025758-01 ), the Deutsche Forschungsgemeinschaft (research fellowship to SE) and the NARSAD Young Investigator Award (to S.E). Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd.",

year = "2015",

month = oct,

day = "30",

doi = "10.1016/j.pscychresns.2015.08.008",

language = "English (US)",

volume = "234",

pages = "74--83",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Brain structure and function correlates of cognitive subtypes in schizophrenia

AU - Geisler, Daniel

AU - Walton, Esther

AU - Naylor, Melissa

AU - Roessner, Veit

AU - Lim, Kelvin O.

AU - Charles Schulz, S.

AU - Gollub, Randy L.

AU - Calhoun, Vince D.

AU - Sponheim, Scott R.

AU - Ehrlich, Stefan

N1 - Funding Information: This work was supported by the National Institutes of Health (NIH/NCRR P41RR14075 , 1RC1MH089257 , and R01EB005846 ) (to VDC), Department of Energy ( DE-FG02-99ER62764 ), Mind Research Network , Morphometry BIRN ( 1U24, RR021382A ), Function BIRN ( U24RR021992-01 , NIH.NCRR MO1 RR025758-01 ), the Deutsche Forschungsgemeinschaft (research fellowship to SE) and the NARSAD Young Investigator Award (to S.E). Publisher Copyright: © 2015 Elsevier Ireland Ltd.

PY - 2015/10/30

Y1 - 2015/10/30

N2 - Stable neuropsychological deficits may provide a reliable basis for identifying etiological subtypes of schizophrenia. The aim of this study was to identify clusters of individuals with schizophrenia based on dimensions of neuropsychological performance, and to characterize their neural correlates. We acquired neuropsychological data as well as structural and functional magnetic resonance imaging from 129 patients with schizophrenia and 165 healthy controls. We derived eight cognitive dimensions and subsequently applied a cluster analysis to identify possible schizophrenia subtypes. Analyses suggested the following four cognitive clusters of schizophrenia: (1) Diminished Verbal Fluency, (2) Diminished Verbal Memory and Poor Motor Control, (3) Diminished Face Memory and Slowed Processing, and (4) Diminished Intellectual Function. The clusters were characterized by a specific pattern of structural brain changes in areas such as Wernicke's area, lingual gyrus and occipital face area, and hippocampus as well as differences in working memory-elicited neural activity in several fronto-parietal brain regions. Separable measures of cognitive function appear to provide a method for deriving cognitive subtypes meaningfully related to brain structure and function. Because the present study identified brain-based neural correlates of the cognitive clusters, the proposed groups of individuals with schizophrenia have some external validity.

AB - Stable neuropsychological deficits may provide a reliable basis for identifying etiological subtypes of schizophrenia. The aim of this study was to identify clusters of individuals with schizophrenia based on dimensions of neuropsychological performance, and to characterize their neural correlates. We acquired neuropsychological data as well as structural and functional magnetic resonance imaging from 129 patients with schizophrenia and 165 healthy controls. We derived eight cognitive dimensions and subsequently applied a cluster analysis to identify possible schizophrenia subtypes. Analyses suggested the following four cognitive clusters of schizophrenia: (1) Diminished Verbal Fluency, (2) Diminished Verbal Memory and Poor Motor Control, (3) Diminished Face Memory and Slowed Processing, and (4) Diminished Intellectual Function. The clusters were characterized by a specific pattern of structural brain changes in areas such as Wernicke's area, lingual gyrus and occipital face area, and hippocampus as well as differences in working memory-elicited neural activity in several fronto-parietal brain regions. Separable measures of cognitive function appear to provide a method for deriving cognitive subtypes meaningfully related to brain structure and function. Because the present study identified brain-based neural correlates of the cognitive clusters, the proposed groups of individuals with schizophrenia have some external validity.

KW - Cluster analysis

KW - Cognitive subtypes

KW - Cortical thickness

KW - Neural correlates

KW - Neuropsychological performance

KW - Schizophrenia

KW - Subcortical volume

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=84948710985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948710985&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2015.08.008

DO - 10.1016/j.pscychresns.2015.08.008

M3 - Article

C2 - 26341950

AN - SCOPUS:84948710985

SN - 0925-4927

VL - 234

SP - 74

EP - 83

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

IS - 1

ER -

Brain structure and function correlates of cognitive subtypes in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this