TY - CHAP
T1 - Brain stimulation therapies for neuropsychiatric disease †
AU - Holtzheimer, Paul E.
AU - Kosel, Markus
AU - Schlaepfer, Thomas
PY - 2012
Y1 - 2012
N2 - Electroconvulsive therapy (ECT) is the most effective acute treatment for a major depressive episode. However, some patients do not achieve symptomatic remission with ECT, many patients cannot tolerate the cognitive side-effects, and the relapse rate over several months is high. In an effort to find treatments that are as effective as, or more effective than, ECT, better tolerated, and associated with long-term maintenance of antidepressant effects, increasing attention has focused on a variety of brain stimulation therapies, including: vagus nerve stimulation, transcranial magnetic stimulation, magnetic seizure therapy, transcranial direct current stimulation, and deep-brain stimulation. In this chapter, we review the history, strengths, and weaknesses of ECT as a treatment for depression, followed by a detailed discussion of the available data supporting safety and efficacy of other brain stimulation therapies. As research on these novel treatment modalities progresses, it is hoped that improved treatment for depression will be achieved. Additionally, these modalities offer unique opportunities to study the neurobiology of disease.
AB - Electroconvulsive therapy (ECT) is the most effective acute treatment for a major depressive episode. However, some patients do not achieve symptomatic remission with ECT, many patients cannot tolerate the cognitive side-effects, and the relapse rate over several months is high. In an effort to find treatments that are as effective as, or more effective than, ECT, better tolerated, and associated with long-term maintenance of antidepressant effects, increasing attention has focused on a variety of brain stimulation therapies, including: vagus nerve stimulation, transcranial magnetic stimulation, magnetic seizure therapy, transcranial direct current stimulation, and deep-brain stimulation. In this chapter, we review the history, strengths, and weaknesses of ECT as a treatment for depression, followed by a detailed discussion of the available data supporting safety and efficacy of other brain stimulation therapies. As research on these novel treatment modalities progresses, it is hoped that improved treatment for depression will be achieved. Additionally, these modalities offer unique opportunities to study the neurobiology of disease.
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U2 - 10.1016/B978-0-444-52002-9.00041-3
DO - 10.1016/B978-0-444-52002-9.00041-3
M3 - Chapter
C2 - 22608652
AN - SCOPUS:84861135680
T3 - Handbook of Clinical Neurology
SP - 681
EP - 695
BT - Handbook of Clinical Neurology
PB - Elsevier B.V.
ER -