Brain potentials measured during a Go/NoGo task predict completion of substance abuse treatment

Vaughn R. Steele, Brandi C. Fink, J. Michael Maurer, Mohammad R. Arbabshirani, Charles H. Wilber, Adam J. Jaffe, Anna Sidz, Godfrey D. Pearlson, Vince Daniel Calhoun, Vincent P. Clark, Kent A. Kiehl

Research output: Contribution to journalArticle

Abstract

Background U.S. nationwide estimates indicate that 50% to 80% of prisoners have a history of substance abuse or dependence. Tailoring substance abuse treatment to specific needs of incarcerated individuals could improve effectiveness of treating substance dependence and preventing drug abuse relapse. We tested whether pretreatment neural measures of a response inhibition (Go/NoGo) task would predict which individuals would or would not complete a 12-week cognitive behavioral substance abuse treatment program. Methods Adult incarcerated participants (n = 89; women n = 55) who volunteered for substance abuse treatment performed a Go/NoGo task while event-related potentials (ERPs) were recorded. Stimulus- and response-locked ERPs were compared between participants who completed (n = 68; women = 45) and discontinued (n = 21; women = 10) treatment. Results As predicted, stimulus-locked P2, response-locked error-related negativity (ERN/Ne), and response-locked error positivity (Pe), measured with windowed time-domain and principal component analysis, differed between groups. Using logistic regression and support-vector machine (i.e., pattern classifiers) models, P2 and Pe predicted treatment completion above and beyond other measures (i.e., N2, P300, ERN/Ne, age, sex, IQ, impulsivity, depression, anxiety, motivation for change, and years of drug abuse). Conclusions Participants who discontinued treatment exhibited deficiencies in sensory gating, as indexed by smaller P2; error-monitoring, as indexed by smaller ERN/Ne; and adjusting response strategy posterror, as indexed by larger Pe. The combination of P2 and Pe reliably predicted 83.33% of individuals who discontinued treatment. These results may help in the development of individualized therapies, which could lead to more favorable, long-term outcomes.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalBiological Psychiatry
Volume76
Issue number1
DOIs
StatePublished - Jul 1 2014
Externally publishedYes

Fingerprint

Substance-Related Disorders
Brain
Therapeutics
Evoked Potentials
Sensory Gating
Prisoners
Impulsive Behavior
Principal Component Analysis
Motivation
Anxiety
Logistic Models
Depression
Recurrence

Keywords

  • Drug treatment
  • event-related potentials
  • pattern classifier
  • principal component analysis
  • response errors
  • response inhibition
  • support vector machine

ASJC Scopus subject areas

  • Biological Psychiatry
  • Medicine(all)

Cite this

Steele, V. R., Fink, B. C., Maurer, J. M., Arbabshirani, M. R., Wilber, C. H., Jaffe, A. J., ... Kiehl, K. A. (2014). Brain potentials measured during a Go/NoGo task predict completion of substance abuse treatment. Biological Psychiatry, 76(1), 75-83. https://doi.org/10.1016/j.biopsych.2013.09.030

Brain potentials measured during a Go/NoGo task predict completion of substance abuse treatment. / Steele, Vaughn R.; Fink, Brandi C.; Maurer, J. Michael; Arbabshirani, Mohammad R.; Wilber, Charles H.; Jaffe, Adam J.; Sidz, Anna; Pearlson, Godfrey D.; Calhoun, Vince Daniel; Clark, Vincent P.; Kiehl, Kent A.

In: Biological Psychiatry, Vol. 76, No. 1, 01.07.2014, p. 75-83.

Research output: Contribution to journalArticle

Steele, VR, Fink, BC, Maurer, JM, Arbabshirani, MR, Wilber, CH, Jaffe, AJ, Sidz, A, Pearlson, GD, Calhoun, VD, Clark, VP & Kiehl, KA 2014, 'Brain potentials measured during a Go/NoGo task predict completion of substance abuse treatment', Biological Psychiatry, vol. 76, no. 1, pp. 75-83. https://doi.org/10.1016/j.biopsych.2013.09.030
Steele, Vaughn R. ; Fink, Brandi C. ; Maurer, J. Michael ; Arbabshirani, Mohammad R. ; Wilber, Charles H. ; Jaffe, Adam J. ; Sidz, Anna ; Pearlson, Godfrey D. ; Calhoun, Vince Daniel ; Clark, Vincent P. ; Kiehl, Kent A. / Brain potentials measured during a Go/NoGo task predict completion of substance abuse treatment. In: Biological Psychiatry. 2014 ; Vol. 76, No. 1. pp. 75-83.
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abstract = "Background U.S. nationwide estimates indicate that 50{\%} to 80{\%} of prisoners have a history of substance abuse or dependence. Tailoring substance abuse treatment to specific needs of incarcerated individuals could improve effectiveness of treating substance dependence and preventing drug abuse relapse. We tested whether pretreatment neural measures of a response inhibition (Go/NoGo) task would predict which individuals would or would not complete a 12-week cognitive behavioral substance abuse treatment program. Methods Adult incarcerated participants (n = 89; women n = 55) who volunteered for substance abuse treatment performed a Go/NoGo task while event-related potentials (ERPs) were recorded. Stimulus- and response-locked ERPs were compared between participants who completed (n = 68; women = 45) and discontinued (n = 21; women = 10) treatment. Results As predicted, stimulus-locked P2, response-locked error-related negativity (ERN/Ne), and response-locked error positivity (Pe), measured with windowed time-domain and principal component analysis, differed between groups. Using logistic regression and support-vector machine (i.e., pattern classifiers) models, P2 and Pe predicted treatment completion above and beyond other measures (i.e., N2, P300, ERN/Ne, age, sex, IQ, impulsivity, depression, anxiety, motivation for change, and years of drug abuse). Conclusions Participants who discontinued treatment exhibited deficiencies in sensory gating, as indexed by smaller P2; error-monitoring, as indexed by smaller ERN/Ne; and adjusting response strategy posterror, as indexed by larger Pe. The combination of P2 and Pe reliably predicted 83.33{\%} of individuals who discontinued treatment. These results may help in the development of individualized therapies, which could lead to more favorable, long-term outcomes.",
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N2 - Background U.S. nationwide estimates indicate that 50% to 80% of prisoners have a history of substance abuse or dependence. Tailoring substance abuse treatment to specific needs of incarcerated individuals could improve effectiveness of treating substance dependence and preventing drug abuse relapse. We tested whether pretreatment neural measures of a response inhibition (Go/NoGo) task would predict which individuals would or would not complete a 12-week cognitive behavioral substance abuse treatment program. Methods Adult incarcerated participants (n = 89; women n = 55) who volunteered for substance abuse treatment performed a Go/NoGo task while event-related potentials (ERPs) were recorded. Stimulus- and response-locked ERPs were compared between participants who completed (n = 68; women = 45) and discontinued (n = 21; women = 10) treatment. Results As predicted, stimulus-locked P2, response-locked error-related negativity (ERN/Ne), and response-locked error positivity (Pe), measured with windowed time-domain and principal component analysis, differed between groups. Using logistic regression and support-vector machine (i.e., pattern classifiers) models, P2 and Pe predicted treatment completion above and beyond other measures (i.e., N2, P300, ERN/Ne, age, sex, IQ, impulsivity, depression, anxiety, motivation for change, and years of drug abuse). Conclusions Participants who discontinued treatment exhibited deficiencies in sensory gating, as indexed by smaller P2; error-monitoring, as indexed by smaller ERN/Ne; and adjusting response strategy posterror, as indexed by larger Pe. The combination of P2 and Pe reliably predicted 83.33% of individuals who discontinued treatment. These results may help in the development of individualized therapies, which could lead to more favorable, long-term outcomes.

AB - Background U.S. nationwide estimates indicate that 50% to 80% of prisoners have a history of substance abuse or dependence. Tailoring substance abuse treatment to specific needs of incarcerated individuals could improve effectiveness of treating substance dependence and preventing drug abuse relapse. We tested whether pretreatment neural measures of a response inhibition (Go/NoGo) task would predict which individuals would or would not complete a 12-week cognitive behavioral substance abuse treatment program. Methods Adult incarcerated participants (n = 89; women n = 55) who volunteered for substance abuse treatment performed a Go/NoGo task while event-related potentials (ERPs) were recorded. Stimulus- and response-locked ERPs were compared between participants who completed (n = 68; women = 45) and discontinued (n = 21; women = 10) treatment. Results As predicted, stimulus-locked P2, response-locked error-related negativity (ERN/Ne), and response-locked error positivity (Pe), measured with windowed time-domain and principal component analysis, differed between groups. Using logistic regression and support-vector machine (i.e., pattern classifiers) models, P2 and Pe predicted treatment completion above and beyond other measures (i.e., N2, P300, ERN/Ne, age, sex, IQ, impulsivity, depression, anxiety, motivation for change, and years of drug abuse). Conclusions Participants who discontinued treatment exhibited deficiencies in sensory gating, as indexed by smaller P2; error-monitoring, as indexed by smaller ERN/Ne; and adjusting response strategy posterror, as indexed by larger Pe. The combination of P2 and Pe reliably predicted 83.33% of individuals who discontinued treatment. These results may help in the development of individualized therapies, which could lead to more favorable, long-term outcomes.

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