TY - JOUR
T1 - Brain Peptides Secreted by Gut Tumors
AU - Snyder, Solomon H.
AU - Uhl, George R.
AU - Miller, Richard
PY - 1978/6/1
Y1 - 1978/6/1
N2 - To the Editor: Several peptides are neurotransmitter candidates in the brain and are also localized to the gastrointestinal tract and associated organs such as the pancreas. Circulating levels of each of these peptides elicit characteristic vascular and autonomic effects. For example, tumors secreting somatostatin are associated with hyperglycemia, hypoinsulinemia and hyperglucagonemia.1,2 We are writing to suggest that other hitherto undescribed peptide-secreting tumors might be identified on the basis of their physiologic effects. Neurotensin, a 13-amino acid peptide, is localized to neurons in the brain and to apparently secretory cells in the small intestine. Parenterally injected neurotensin produces hyperglycemia, with hyperglucagonemia. No extract is available for articles shorter than 400 words.
AB - To the Editor: Several peptides are neurotransmitter candidates in the brain and are also localized to the gastrointestinal tract and associated organs such as the pancreas. Circulating levels of each of these peptides elicit characteristic vascular and autonomic effects. For example, tumors secreting somatostatin are associated with hyperglycemia, hypoinsulinemia and hyperglucagonemia.1,2 We are writing to suggest that other hitherto undescribed peptide-secreting tumors might be identified on the basis of their physiologic effects. Neurotensin, a 13-amino acid peptide, is localized to neurons in the brain and to apparently secretory cells in the small intestine. Parenterally injected neurotensin produces hyperglycemia, with hyperglucagonemia. No extract is available for articles shorter than 400 words.
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U2 - 10.1056/NEJM197806012982213
DO - 10.1056/NEJM197806012982213
M3 - Letter
C2 - 26025
AN - SCOPUS:0017982694
SN - 0028-4793
VL - 298
SP - 1259
EP - 1260
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 22
ER -