Brain O2 consumption and glutamate release during hypoglycemic coma in piglets are temperature sensitive

R. N. Ichord, F. J. Northington, D. Van Wylen, M. V. Johnston, C. Kwon, R. J. Traystman

Research output: Contribution to journalArticlepeer-review

Abstract

Hypoglycemic injury in the mature brain is mediated by excitotoxicity, which is worsened by disordered cellular energy metabolism. The role of excitotoxicity in relation to brain energy metabolism during hypoglycemia has not been studied in the immature brain. Brain oxygen consumption (CMR(O2)) increases during hypoglycemia in piglets, whereas CMR(O2) decreases in adult pig models. We tested the hypothesis that increased CMR(O2) during hypoglycemic coma is temperature dependent and coincides with increased excitatory amino acids (EAA). We measured cerebral blood flow (CBF), CMR(O2), and cortical microdialysate EAA in pentobarbital-anesthetized piglets during hypoglycemic coma and during 2 h of recovery and in normoglycemic controls. In warmed animals brain temperature was kept normothermic (38.5°C). In unwarmed animals brain temperature was allowed to fall (37.6°C). During hypoglycemia CBF increased similarly in warmed animals and unwarmed animals; CMR(O2) increased in warmed animals but not unwarmed animals. Glutamate increased during coma and increased more in warmed animals than unwarmed animals but normalized quickly during recovery. EEG recovered earlier in unwarmed animals. We conclude that during a hypoglycemic coma in the immature brain, CMR(O2) and glutamate are increased in a temperature- dependent manner.

Original languageEnglish (US)
Pages (from-to)H2053-H2062
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume276
Issue number6 45-6
DOIs
StatePublished - Jun 1999

Keywords

  • Cerebral blood flow
  • Electroencephalogram
  • Excitotoxicity
  • Microdialysis
  • Newborn

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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