Œdème cérébral par lésion de la barrière hématoencéphalique: Mécanismes et diagnostic

Translated title of the contribution: Brain oedema following blood-brain barrier disruption: Mechanisms and diagnosis

J. F. Payen, B. Fauvage, D. Falcon, P. Lavagne

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Brain oedema following blood-brain barrier (BBB) disruption, or vasogenic oedema, is present in most cases of brain oedema. According to the Starling's law, water, ions and plasma proteins cross the BBB toward the interstitium if the driving forces for transmural bulk flow are excessive (mechanical origin) and/or if the BBB permeability is enhanced (chemical origin). Both mechanisms coexist in most cases. Excessive elevation of the gradient of hydrostatic pressure with lost of cerebral autoregulation has been proved in ischaemia/reperfusion and trauma, and suggested in acute mountain sickness and eclampsia. The BBB permeability can be enhanced by immediate (chemical mediators) or delayed (cellular infiltration) inflammatory response, or by alteration of the membrane integrity. This later can be transient (hyperosmolar BBB disruption), or permanent by activation of matrix metalloproteinase or by neovascularization with BBB breakdown. The reference method for the diagnosis of vasogenic oedema is the MRI diffusion-weighted imaging.

Translated title of the contributionBrain oedema following blood-brain barrier disruption: Mechanisms and diagnosis
Original languageFrench
Pages (from-to)220-225
Number of pages6
JournalAnnales Francaises d'Anesthesie et de Reanimation
Issue number3
StatePublished - Mar 2003


  • Blood-brain barrier
  • Diffusion imaging
  • Magnetic resonance imaging
  • Vasogenic oedema

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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