Brain Metastases

Balamurugan A. Vellayappan, Arjun Sahgal, Kristin J. Redmond, Lia M. Halasz, Eric L. Chang, Simon S. Lo

Research output: Chapter in Book/Report/Conference proceedingChapter


Brain metastases (BM) cause significant morbidity and mortality, with profound personal and societal impact. Historically, surgery and whole-brain radiotherapy (WBRT) were the mainstays of management. WBRT alone has been shown to have limited role for durable local control, and there are concerns regarding its impact on quality of life (QoL) and neurocognitive function. Advances in systemic therapeutics have afforded improved control of extracranial disease and paved the way for improved survival outcomes. In parallel, the overarching goals of BM management are to provide durable intracranial control and good QoL, with minimal long-term toxicities, and, if possible, to prolong survival. However, there remain significant controversies within the oncology community about how these goals should be achieved. Herein, we will review various management strategies, including the role of stereotactic radiosurgery (SRS) and methods to mitigate long-term toxicity of WBRT.

Original languageEnglish (US)
Title of host publicationMedical Radiology
Number of pages30
StatePublished - 2020

Publication series

NameMedical Radiology
ISSN (Print)0942-5373
ISSN (Electronic)2197-4187

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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