Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task

Henry H. Holcomb, Barry Gordon, Harry L. Loats, Edward Gastineau, Zuo Zhao, Deborah Medoff, Robert F Dannals, Roger Woods, Carol A. Tamminga

Research output: Contribution to journalArticle

Abstract

Using positron emission tomography with the tracer 18-fluoro-D-deoxyglucose, we assessed regional cerebral glucose utilization patterns (rCMRglu) associated with three performance levels in a forced choice, tone recognition task. Four normal subjects responded with one hand when they heard a high-frequency tone (1500 Hz), and with the other hand when they recognized a low-frequency tone (750 Hz). The EASY (EAS) condition accuracy average was 96%, the INTERMEDIATE level accuracy averaged 89%, and the DIFFICULT (DIF) recognition task accuracy average was 77%. Statistical parametric mapping (SPM94) analysis revealed that the DIF minus EAS contrast is associated with a marked metabolic elevation in the right middle and inferior temporal gyri and the gyrus fusiformis. The EAS minus DIF contrast revealed greater rCMRglu in the right medial geniculate body. Enhanced activity in right temporal lobe structures may reflect a role in auditory memory and 'image' visualization The medial geniculate enhancement may reflect tone frequency assessment.

Original languageEnglish (US)
Pages (from-to)1013-1022
Number of pages10
JournalBiological Psychiatry
Volume39
Issue number12
DOIs
StatePublished - Jun 15 1996

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Temporal Lobe
Brain
Hand
Geniculate Bodies
Deoxyglucose
Positron-Emission Tomography
Glucose
Recognition (Psychology)

Keywords

  • Attention
  • Cortex
  • FDG
  • Positron emission tomography
  • Thalamus
  • Tone recognition

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task. / Holcomb, Henry H.; Gordon, Barry; Loats, Harry L.; Gastineau, Edward; Zhao, Zuo; Medoff, Deborah; Dannals, Robert F; Woods, Roger; Tamminga, Carol A.

In: Biological Psychiatry, Vol. 39, No. 12, 15.06.1996, p. 1013-1022.

Research output: Contribution to journalArticle

Holcomb, Henry H. ; Gordon, Barry ; Loats, Harry L. ; Gastineau, Edward ; Zhao, Zuo ; Medoff, Deborah ; Dannals, Robert F ; Woods, Roger ; Tamminga, Carol A. / Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task. In: Biological Psychiatry. 1996 ; Vol. 39, No. 12. pp. 1013-1022.
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