Brain mapping with functional MR imaging: Comparison of gradient-echo-based exogenous and endogenous contrast techniques

Venkata Mattay, Daniel Weinberger, Fernando A. Barrios, Geoffrey S. Sobering, Kathryn J. Kotrla, Peter Van Gelderen, Jeff H. Duyn, Roy H. Sexton, Chrit T W Moonen, Joseph A. Frank

Research output: Contribution to journalReview article

Abstract

PURPOSE: To compare directly the two most widely used methods of functional magnetic resonance (MR) imaging - dynamic contrast material-enhanced MR imaging and blood oxygenation level-dependent (BOLD) MR imaging. MATERIALS AND METHODS: Five healthy volunteers underwent dynamic contrast-enhanced and BOLD MR imaging with a conventional 1.5-T MR unit during visual stimulation and a dark control state. BOLD studies were performed with a gradient-echo sequence, and dynamic MR imaging was performed with an echo-shifted gradient-echo sequence after intravenous administration of a bolus of gadopentetate dimeglumine. RESULTS: A significantly greater percentage signal change was found with dynamic MR imaging than with the BOLD technique. The extent of area activated was also significantly greater. CONCLUSION: With standard clinical imagers and these gradient-echo-based techniques, greater percentage activation and area of activation can be achieved with dynamic MR imaging than with BOLD MR imaging.

Original languageEnglish (US)
Pages (from-to)687-691
Number of pages5
JournalRadiology
Volume194
Issue number3
StatePublished - Mar 1995
Externally publishedYes

Fingerprint

Brain Mapping
Magnetic Resonance Imaging
Photic Stimulation
Gadolinium DTPA
Intravenous Administration
Contrast Media
Healthy Volunteers
Magnetic Resonance Spectroscopy

Keywords

  • Blood, flow dynamics, 10.919
  • Brain, function, 10.919
  • Brain, MR, 17.121412, 17.121416, 17.12144
  • Magnetic resonance (MR), rapid imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Mattay, V., Weinberger, D., Barrios, F. A., Sobering, G. S., Kotrla, K. J., Van Gelderen, P., ... Frank, J. A. (1995). Brain mapping with functional MR imaging: Comparison of gradient-echo-based exogenous and endogenous contrast techniques. Radiology, 194(3), 687-691.

Brain mapping with functional MR imaging : Comparison of gradient-echo-based exogenous and endogenous contrast techniques. / Mattay, Venkata; Weinberger, Daniel; Barrios, Fernando A.; Sobering, Geoffrey S.; Kotrla, Kathryn J.; Van Gelderen, Peter; Duyn, Jeff H.; Sexton, Roy H.; Moonen, Chrit T W; Frank, Joseph A.

In: Radiology, Vol. 194, No. 3, 03.1995, p. 687-691.

Research output: Contribution to journalReview article

Mattay, V, Weinberger, D, Barrios, FA, Sobering, GS, Kotrla, KJ, Van Gelderen, P, Duyn, JH, Sexton, RH, Moonen, CTW & Frank, JA 1995, 'Brain mapping with functional MR imaging: Comparison of gradient-echo-based exogenous and endogenous contrast techniques', Radiology, vol. 194, no. 3, pp. 687-691.
Mattay, Venkata ; Weinberger, Daniel ; Barrios, Fernando A. ; Sobering, Geoffrey S. ; Kotrla, Kathryn J. ; Van Gelderen, Peter ; Duyn, Jeff H. ; Sexton, Roy H. ; Moonen, Chrit T W ; Frank, Joseph A. / Brain mapping with functional MR imaging : Comparison of gradient-echo-based exogenous and endogenous contrast techniques. In: Radiology. 1995 ; Vol. 194, No. 3. pp. 687-691.
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AU - Sobering, Geoffrey S.

AU - Kotrla, Kathryn J.

AU - Van Gelderen, Peter

AU - Duyn, Jeff H.

AU - Sexton, Roy H.

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N2 - PURPOSE: To compare directly the two most widely used methods of functional magnetic resonance (MR) imaging - dynamic contrast material-enhanced MR imaging and blood oxygenation level-dependent (BOLD) MR imaging. MATERIALS AND METHODS: Five healthy volunteers underwent dynamic contrast-enhanced and BOLD MR imaging with a conventional 1.5-T MR unit during visual stimulation and a dark control state. BOLD studies were performed with a gradient-echo sequence, and dynamic MR imaging was performed with an echo-shifted gradient-echo sequence after intravenous administration of a bolus of gadopentetate dimeglumine. RESULTS: A significantly greater percentage signal change was found with dynamic MR imaging than with the BOLD technique. The extent of area activated was also significantly greater. CONCLUSION: With standard clinical imagers and these gradient-echo-based techniques, greater percentage activation and area of activation can be achieved with dynamic MR imaging than with BOLD MR imaging.

AB - PURPOSE: To compare directly the two most widely used methods of functional magnetic resonance (MR) imaging - dynamic contrast material-enhanced MR imaging and blood oxygenation level-dependent (BOLD) MR imaging. MATERIALS AND METHODS: Five healthy volunteers underwent dynamic contrast-enhanced and BOLD MR imaging with a conventional 1.5-T MR unit during visual stimulation and a dark control state. BOLD studies were performed with a gradient-echo sequence, and dynamic MR imaging was performed with an echo-shifted gradient-echo sequence after intravenous administration of a bolus of gadopentetate dimeglumine. RESULTS: A significantly greater percentage signal change was found with dynamic MR imaging than with the BOLD technique. The extent of area activated was also significantly greater. CONCLUSION: With standard clinical imagers and these gradient-echo-based techniques, greater percentage activation and area of activation can be achieved with dynamic MR imaging than with BOLD MR imaging.

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