PURPOSE: To compare directly the two most widely used methods of functional magnetic resonance (MR) imaging - dynamic contrast material-enhanced MR imaging and blood oxygenation level-dependent (BOLD) MR imaging. MATERIALS AND METHODS: Five healthy volunteers underwent dynamic contrast-enhanced and BOLD MR imaging with a conventional 1.5-T MR unit during visual stimulation and a dark control state. BOLD studies were performed with a gradient-echo sequence, and dynamic MR imaging was performed with an echo-shifted gradient-echo sequence after intravenous administration of a bolus of gadopentetate dimeglumine. RESULTS: A significantly greater percentage signal change was found with dynamic MR imaging than with the BOLD technique. The extent of area activated was also significantly greater. CONCLUSION: With standard clinical imagers and these gradient-echo-based techniques, greater percentage activation and area of activation can be achieved with dynamic MR imaging than with BOLD MR imaging.
- Blood, flow dynamics, 10.919
- Brain, MR, 17.121412, 17.121416, 17.12144
- Brain, function, 10.919
- Magnetic resonance (MR), rapid imaging
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging