Brain, liver, and adipose tissue erucic and very long chain fatty acid levels in adrenoleukodystrophy patients treated with glyceryl trierucate and trioleate oils (Lorenzo's Oil)

Magnhild Rasmussen, Ann B. Moser, Janet Borel, Surinder Khangoora, Hugo W. Moser

Research output: Contribution to journalArticle

Abstract

Brain, liver, and adipose lipids were studied in the postmortem tissues of four adrenoleukodystrophy patients who had been treated with a mixture of glyceryl trioleate and trierucate olis ("Lorenzo's Oil") and compared to 7 untreated ALD patients and 3 controls. The dietary therapy appeared to reduce the levels of saturated very long chain fatty acids in the plasma, adipose tissue and liver; in the brain they were reduced in only one of the four patients. While substantial amounts of erucic acid were present in some of the tissues even 12 months after therapy had been discontinued, the levels in brain did not exceed those in controls at any time. The failure of erucic acid to enter the brain in significant quantity may be a factor in the disappointing results of dietary therapy for adrenoleukodystrophy.

Original languageEnglish (US)
Pages (from-to)1073-1082
Number of pages10
JournalNeurochemical Research
Volume19
Issue number8
DOIs
StatePublished - Aug 1994

Fingerprint

Adrenoleukodystrophy
Liver
Adipose Tissue
Brain
Oils
Fatty Acids
Tissue
Therapeutics
Lipids
Plasmas
Lorenzo's oil
trierucate
erucic acid

Keywords

  • Adrenoleukodystrphy
  • dietary therapy
  • erucic acid
  • very long chain fatty acids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Brain, liver, and adipose tissue erucic and very long chain fatty acid levels in adrenoleukodystrophy patients treated with glyceryl trierucate and trioleate oils (Lorenzo's Oil). / Rasmussen, Magnhild; Moser, Ann B.; Borel, Janet; Khangoora, Surinder; Moser, Hugo W.

In: Neurochemical Research, Vol. 19, No. 8, 08.1994, p. 1073-1082.

Research output: Contribution to journalArticle

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