Brain language: Uncovering functional connectivity codes

Victor M. Vergara, Vince D. Calhoun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The functional connectivity within a specific set of brain networks (or domain) can assume different configurations known as domain states that change with time. Recently, we proposed an information theoretical framework that models the finite set of domain states as elements of an alphabet. Significant bits of information have been found to be shared among domains, but specific domain codification was not explored. This work describes a method to identify code words used to transmit and receive information between the cerebrum and the cerebellum based on dynamic domain connectivity estimated from functional magnetic resonance imaging (fMRI). Following the theory of jointly typical sets, the developed method identifies the codeword length and the specific combination of domain states on each codeword. Resting state fMRI data was taken from 121 subjects with no significant age difference between males and females. Group independent component analysis was utilized to identify important brain networks and group them in a cerebellum and six other domains representing the cerebrum. The amount of information between the cerebellum, the executive control and sensorimotor domains showed a statistically significant number of bits. The proposed method quantified specific temporal sequences of domain states encoded within bits shared between cerebellum and cerebrum.

Original languageEnglish (US)
Title of host publicationConference Record of 51st Asilomar Conference on Signals, Systems and Computers, ACSSC 2017
EditorsMichael B. Matthews
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1309-1312
Number of pages4
ISBN (Electronic)9781538618233
DOIs
StatePublished - Apr 10 2018
Event51st Asilomar Conference on Signals, Systems and Computers, ACSSC 2017 - Pacific Grove, United States
Duration: Oct 29 2017Nov 1 2017

Publication series

NameConference Record of 51st Asilomar Conference on Signals, Systems and Computers, ACSSC 2017
Volume2017-October

Other

Other51st Asilomar Conference on Signals, Systems and Computers, ACSSC 2017
Country/TerritoryUnited States
CityPacific Grove
Period10/29/1711/1/17

Keywords

  • brain
  • cerebellum
  • dynamic functional connectivity
  • information theory
  • mutual information

ASJC Scopus subject areas

  • Control and Optimization
  • Computer Networks and Communications
  • Hardware and Architecture
  • Signal Processing
  • Biomedical Engineering
  • Instrumentation

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