Brain energy metabolism and blood flow differences in healthy aging

Joel Aanerud, Per Borghammer, M. Mallar Chakravarty, Kim Vang, Anders B. Rodell, Kristjana Y. Jónsdottir, Arne Møller, Mahmoud Ashkanian, Manouchehr S. Vafaee, Peter Iversen, Peter Johannsen, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

Cerebral metabolic rate of oxygen consumption (CMRO 2), cerebral blood flow (CBF), and oxygen extraction fraction (OEF) are important indices of healthy aging of the brain. Although a frequent topic of study, changes of CBF and CMRO 2 during normal aging are still controversial, as some authors find decreases of both CBF and CMRO 2 but increased OEF, while others find no change, and yet other find divergent changes. In this reanalysis of previously published results from positron emission tomography of healthy volunteers, we determined CMRO 2 and CBF in 66 healthy volunteers aged 21 to 81 years. The magnitudes of CMRO 2 and CBF declined in large parts of the cerebral cortex, including association areas, but the primary motor and sensory areas were relatively spared. We found significant increases of OEF in frontal and parietal cortices, excluding primary motor and somatosensory regions, and in the temporal cortex. Because of the inverse relation between OEF and capillary oxygen tension, increased OEF can compromise oxygen delivery to neurons, with possible perturbation of energy turnover. The results establish a possible mechanism of progression from healthy to unhealthy brain aging, as the regions most affected by age are the areas that are most vulnerable to neurodegeneration.

Original languageEnglish (US)
Pages (from-to)1177-1187
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Cerebrovascular Circulation
Energy Metabolism
Oxygen
Brain
Healthy Volunteers
Parietal Lobe
Motor Cortex
Frontal Lobe
Temporal Lobe
Oxygen Consumption
Positron-Emission Tomography
Cerebral Cortex
Neurons

Keywords

  • Aging
  • energy metabolism
  • neurovascular coupling
  • positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Aanerud, J., Borghammer, P., Mallar Chakravarty, M., Vang, K., Rodell, A. B., Jónsdottir, K. Y., ... Gjedde, A. (2012). Brain energy metabolism and blood flow differences in healthy aging. Journal of Cerebral Blood Flow and Metabolism, 32(7), 1177-1187. https://doi.org/10.1038/jcbfm.2012.18

Brain energy metabolism and blood flow differences in healthy aging. / Aanerud, Joel; Borghammer, Per; Mallar Chakravarty, M.; Vang, Kim; Rodell, Anders B.; Jónsdottir, Kristjana Y.; Møller, Arne; Ashkanian, Mahmoud; Vafaee, Manouchehr S.; Iversen, Peter; Johannsen, Peter; Gjedde, Albert.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 32, No. 7, 07.2012, p. 1177-1187.

Research output: Contribution to journalArticle

Aanerud, J, Borghammer, P, Mallar Chakravarty, M, Vang, K, Rodell, AB, Jónsdottir, KY, Møller, A, Ashkanian, M, Vafaee, MS, Iversen, P, Johannsen, P & Gjedde, A 2012, 'Brain energy metabolism and blood flow differences in healthy aging', Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 7, pp. 1177-1187. https://doi.org/10.1038/jcbfm.2012.18
Aanerud J, Borghammer P, Mallar Chakravarty M, Vang K, Rodell AB, Jónsdottir KY et al. Brain energy metabolism and blood flow differences in healthy aging. Journal of Cerebral Blood Flow and Metabolism. 2012 Jul;32(7):1177-1187. https://doi.org/10.1038/jcbfm.2012.18
Aanerud, Joel ; Borghammer, Per ; Mallar Chakravarty, M. ; Vang, Kim ; Rodell, Anders B. ; Jónsdottir, Kristjana Y. ; Møller, Arne ; Ashkanian, Mahmoud ; Vafaee, Manouchehr S. ; Iversen, Peter ; Johannsen, Peter ; Gjedde, Albert. / Brain energy metabolism and blood flow differences in healthy aging. In: Journal of Cerebral Blood Flow and Metabolism. 2012 ; Vol. 32, No. 7. pp. 1177-1187.
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