Abstract
Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.
| Original language | English (US) |
|---|---|
| Article number | 306 |
| Journal | Critical Care |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 16 2018 |
Keywords
- Brain death
- Ethics
- Postmortem organ donation
- Traumatic brain injury
- Ventricular drainage
- Withdrawing life-sustaining measures
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
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Brain death and postmortem organ donation : Report of a questionnaire from the CENTER-TBI study. / Van Veen, Ernest; Van Der Jagt, Mathieu; Cnossen, Maryse C.; Maas, Andrew I.R.; De Beaufort, Inez D.; Menon, David K.; Citerio, Giuseppe; Stocchetti, Nino; Rietdijk, Wim J.R.; Van Dijck, Jeroen T.J.M.; Kompanje, Erwin J.O.; Ackerlund, Cecilia; Adams, Hadie; Agnoletti, Vanni; Allanson, Judith; Amrein, Krisztina; Andaluz, Norberto; Andelic, Nada; Andreassen, Lasse; Antun, Azasevac; Anke, Audny; Antoni, Anna; Ardon, Hilko; Audibert, Gérard; Auslands, Kaspars; Azouvi, Philippe; Azzolini, Maria Luisa; Baciu, Camelia; Badenes, Rafael; Bartels, Ronald; Barzó, Pál; Bauerfeind, Ursula; Beauvais, Romuald; Beer, Ronny; Francisco, Javier Belda; Bellander, Bo Michael; Belli, Antonio; Bellier, Rémy; Benali, Habib; Benard, Thierry; Berardino, Maurizio; Beretta, Luigi; Beynon, Christopher; Bilotta, Federico; Binder, Harald; Biqiri, Erta; Blaabjerg, Morten; Den Boogert, Hugo; Bouzat, Pierre; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo; Carbonara, Marco; Carise, Elsa; Carpenter, K.; Castaño-León, Ana M.; Causin, Francesco; Chevallard, Giorgio; Chieregato, Arturo; Coburn, Mark; Coles, Jonathan; Coles-Kemp, Lizzie; Collett, Johnny; Cooper, Jamie D.; Correia, Marta; Covic, Amra; Curry, Nicola; Czeiter, Endre; Czosnyka, Marek; Dahyot-Fizelier, Claire; Damas, François; Damas, Pierre; Dawes, Helen; De Keyser, Véronique; Della Corte, Francesco; Depreitere, Bart; De Ruiter Godard, C. W.; Dilvesi, Dula; Ding, Shenghao; Dippel, Diederik; Dixit, Abhishek; Donoghue, Emma; Dreier, Jens; Dulière, Guy Loup; Eapen, George; Engemann, Heiko; Ercole, Ari; Esser, Patrick; Ezer, Erzsébet; Fabricius, Martin; Feigin, Valery L.; Feng, Junfeng; Foks, Kelly; Fossi, Francesca; Francony, Gilles; Freo, Ulderico; Frisvold, Shirin; Furmanov, Alex; Gagliardo, Pablo; Galanaud, Damien; Gantner, Dashiell; Gao, Guoyi; Geleijns, Karin; George, Pradeep; Ghuysen, Alexandre; Giga, Lelde; Giraud, Benoit; Glocker, Ben; Golubovic, Jagos; Gomez, Pedro A.; Grossi, Francesca; Gruen, Russell L.; Gupta, Deepak; Haagsma, Juanita A.; Haitsma, Iain; Hartings, Jed A.; Helbok, Raimund; Helseth, Eirik; Hertle, Daniel; Hoedemaekers, Astrid; Hoefer, Stefan; Horton, Lindsay; Huijben, Jilske; Hutchinson, Peter J.; Håberg, Asta Kristine; Jacobs, Bram; Jankowski, Stefan; Jarrett, Mike; Jelaca, Bojan; Jiang, Ji Yao; Jones, Kelly; Kamnitsas, Konstantinos; Karan, Mladen; Katila, Ari; Kaukonen, Maija; Kerforne, Thomas; Kivisaari, Riku; Kolias, Angelos G.; Kolumbán, Bálint; Kolundzija, Ksenija; Kondziella, Daniel; Koskinen, Lars Owe; Kovács, Noémi; Lagares, Alfonso; Lanyon, Linda; Laureys, Steven; Lecky, Fiona; Ledig, Christian; Lefering, Rolf; Legrand, Valerie; Lei, Jin; Levi, Leon; Lightfoot, Roger; Lingsma, Hester; Loeckx, Dirk; Lozano, Angels; MacDonald, Stephen; Maegele, Marc; Majdan, Marek; Major, Sebastian; Manara, Alex; Manley, Geoffrey; Didier, Martin; Martin, Leon Francisco; Martino, Costanza; Maruenda, Armando; Maréchal, Hugues; Masala, Alessandro; Mattern, Julia; McFadyen, Charles; McMahon, Catherine; Melegh, Béla; Menovsky, Tomas; Morganti-Kossmann, Cristina; Mulazzi, Davide; Muraleedharan, Visakh; Murray, Lynnette; Mühlan, Holger; Nair, Nandesh; Negru, Ancuta; Nelson, David; Newcombe, Virginia; Nieboer, Daan; Noirhomme, Quentin; Nyirádi, József; Oddo, Mauro; Oldenbeuving, Annemarie; Oresic, Matej; Ortolano, Fabrizio; Palotie, Aarno; Parizel, Paul M.; Patruno, Adriana; Payen, Jean François; Perera, Natascha; Perlbarg, Vincent; Persona, Paolo; Peul, Wilco; Piippo-Karjalainen, Anna; Floury, Sébastien Pili; Pirinen, Matti; Ples, Horia; Poca, Maria Antonia; Polinder, Suzanne; Pomposo, Inigo; Posti, Jussi; Puybasset, Louis; Radoi, Andreea; Ragauskas, Arminas; Raj, Rahul; Rambadagalla, Malinka; Real, Ruben; Rehorčíková, Veronika; Rhodes, Jonathan; Ripatti, Samuli; Rocka, Saulius; Roe, Cecilie; Roise, Olav; Roks, Gerwin; Rosand, Jonathan; Rosenfeld, Jeffrey; Rosenlund, Christina; Rosenthal, Guy; Rossaint, Rolf; Rossi, Sandra; Rueckert, Daniel; Rusnák, Martin; Sacchi, Marco; Sahakian, Barbara; Sahuquillo, Juan; Sakowitz, Oliver; Sala, Francesca; Sanchez-Porras, Renan; Sandor, Janos; Santos, Edgar; Sasu, Luminita; Savo, Davide; Schäffer, Nadine; Schipper, Inger; Schlößer, Barbara; Schmidt, Silke; Schoechl, Herbert; Schoonman, Guus; Schou, Rico Frederik; Schwendenwein, Elisabeth; Schöll, Michael; Sir, Özcan; Skandsen, Toril; Smakman, Lidwien; Smeets, Dirk; Smielewski, Peter; Sorinola, Abayomi; Stamatakis, Emmanuel; Stanworth, Simon; Steinbüchel, Nicole; Stevanovic, Ana; Stevens, Robert; Stewart, William; Steyerberg, Ewout W.; Sundström, Nina; Synnot, Anneliese; Taccone, Fabio Silvio; Takala, Riikka; Tamás, Viktória; Tanskanen, Päivi; Taylor, Mark Steven; Te Ao, Braden; Tenovuo, Olli; Telgmann, Ralph; Teodorani, Guido; Theadom, Alice; Thomas, Matt; Tibboel, Dick; Tolias, Christos; Tshibanda, Jean Flory Luaba; Trapani, Tony; Tudora, Cristina Maria; Vajkoczy, Peter; Vallance, Shirley; Valeinis, Egils; Van Der Steen, Gregory; Van Der Naalt, Joukje; Van Essen, Thomas A.; Van Hecke, Wim; Van Heugten, Caroline; Van Praag, Dominique; Vyvere, Thijs Vande; Van Waesberghe, Julia; Vanhaudenhuyse, Audrey; Vargiolu, Alessia; Vega, Emmanuel; Velt, Kimberley; Verheyden, Jan; Vespa, Paul M.; Vik, Anne; Vilcinis, Rimantas; Vizzino, Giacinta; Vleggeert-Lankamp, Carmen; Volovici, Victor; Voormolen, Daphne; Vulekovic, Peter; Vámos, Zoltán; Wade, Derick; Wang, Kevin K.W.; Wang, Lei; Wessels, Lars; Wildschut, Eno; Williams, Guy; Wilson, Lindsay; Winkler, Maren K.L.; Wolf, Stefan; Ylén, Peter; Younsi, Alexander; Zaaroor, Menashe; Zhihui, Yang; Ziverte, Agate; Zumbo, Fabrizio.
In: Critical Care, Vol. 22, No. 1, 306, 16.11.2018.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Brain death and postmortem organ donation
T2 - Report of a questionnaire from the CENTER-TBI study
AU - Van Veen, Ernest
AU - Van Der Jagt, Mathieu
AU - Cnossen, Maryse C.
AU - Maas, Andrew I.R.
AU - De Beaufort, Inez D.
AU - Menon, David K.
AU - Citerio, Giuseppe
AU - Stocchetti, Nino
AU - Rietdijk, Wim J.R.
AU - Van Dijck, Jeroen T.J.M.
AU - Kompanje, Erwin J.O.
AU - Ackerlund, Cecilia
AU - Adams, Hadie
AU - Agnoletti, Vanni
AU - Allanson, Judith
AU - Amrein, Krisztina
AU - Andaluz, Norberto
AU - Andelic, Nada
AU - Andreassen, Lasse
AU - Antun, Azasevac
AU - Anke, Audny
AU - Antoni, Anna
AU - Ardon, Hilko
AU - Audibert, Gérard
AU - Auslands, Kaspars
AU - Azouvi, Philippe
AU - Azzolini, Maria Luisa
AU - Baciu, Camelia
AU - Badenes, Rafael
AU - Bartels, Ronald
AU - Barzó, Pál
AU - Bauerfeind, Ursula
AU - Beauvais, Romuald
AU - Beer, Ronny
AU - Francisco, Javier Belda
AU - Bellander, Bo Michael
AU - Belli, Antonio
AU - Bellier, Rémy
AU - Benali, Habib
AU - Benard, Thierry
AU - Berardino, Maurizio
AU - Beretta, Luigi
AU - Beynon, Christopher
AU - Bilotta, Federico
AU - Binder, Harald
AU - Biqiri, Erta
AU - Blaabjerg, Morten
AU - Den Boogert, Hugo
AU - Bouzat, Pierre
AU - Bragge, Peter
AU - Brazinova, Alexandra
AU - Brinck, Vibeke
AU - Brooker, Joanne
AU - Brorsson, Camilla
AU - Buki, Andras
AU - Bullinger, Monika
AU - Calappi, Emiliana
AU - Calvi, Maria Rosa
AU - Cameron, Peter
AU - Lozano, Guillermo Carbayo
AU - Carbonara, Marco
AU - Carise, Elsa
AU - Carpenter, K.
AU - Castaño-León, Ana M.
AU - Causin, Francesco
AU - Chevallard, Giorgio
AU - Chieregato, Arturo
AU - Coburn, Mark
AU - Coles, Jonathan
AU - Coles-Kemp, Lizzie
AU - Collett, Johnny
AU - Cooper, Jamie D.
AU - Correia, Marta
AU - Covic, Amra
AU - Curry, Nicola
AU - Czeiter, Endre
AU - Czosnyka, Marek
AU - Dahyot-Fizelier, Claire
AU - Damas, François
AU - Damas, Pierre
AU - Dawes, Helen
AU - De Keyser, Véronique
AU - Della Corte, Francesco
AU - Depreitere, Bart
AU - De Ruiter Godard, C. W.
AU - Dilvesi, Dula
AU - Ding, Shenghao
AU - Dippel, Diederik
AU - Dixit, Abhishek
AU - Donoghue, Emma
AU - Dreier, Jens
AU - Dulière, Guy Loup
AU - Eapen, George
AU - Engemann, Heiko
AU - Ercole, Ari
AU - Esser, Patrick
AU - Ezer, Erzsébet
AU - Fabricius, Martin
AU - Feigin, Valery L.
AU - Feng, Junfeng
AU - Foks, Kelly
AU - Fossi, Francesca
AU - Francony, Gilles
AU - Freo, Ulderico
AU - Frisvold, Shirin
AU - Furmanov, Alex
AU - Gagliardo, Pablo
AU - Galanaud, Damien
AU - Gantner, Dashiell
AU - Gao, Guoyi
AU - Geleijns, Karin
AU - George, Pradeep
AU - Ghuysen, Alexandre
AU - Giga, Lelde
AU - Giraud, Benoit
AU - Glocker, Ben
AU - Golubovic, Jagos
AU - Gomez, Pedro A.
AU - Grossi, Francesca
AU - Gruen, Russell L.
AU - Gupta, Deepak
AU - Haagsma, Juanita A.
AU - Haitsma, Iain
AU - Hartings, Jed A.
AU - Helbok, Raimund
AU - Helseth, Eirik
AU - Hertle, Daniel
AU - Hoedemaekers, Astrid
AU - Hoefer, Stefan
AU - Horton, Lindsay
AU - Huijben, Jilske
AU - Hutchinson, Peter J.
AU - Håberg, Asta Kristine
AU - Jacobs, Bram
AU - Jankowski, Stefan
AU - Jarrett, Mike
AU - Jelaca, Bojan
AU - Jiang, Ji Yao
AU - Jones, Kelly
AU - Kamnitsas, Konstantinos
AU - Karan, Mladen
AU - Katila, Ari
AU - Kaukonen, Maija
AU - Kerforne, Thomas
AU - Kivisaari, Riku
AU - Kolias, Angelos G.
AU - Kolumbán, Bálint
AU - Kolundzija, Ksenija
AU - Kondziella, Daniel
AU - Koskinen, Lars Owe
AU - Kovács, Noémi
AU - Lagares, Alfonso
AU - Lanyon, Linda
AU - Laureys, Steven
AU - Lecky, Fiona
AU - Ledig, Christian
AU - Lefering, Rolf
AU - Legrand, Valerie
AU - Lei, Jin
AU - Levi, Leon
AU - Lightfoot, Roger
AU - Lingsma, Hester
AU - Loeckx, Dirk
AU - Lozano, Angels
AU - MacDonald, Stephen
AU - Maegele, Marc
AU - Majdan, Marek
AU - Major, Sebastian
AU - Manara, Alex
AU - Manley, Geoffrey
AU - Didier, Martin
AU - Martin, Leon Francisco
AU - Martino, Costanza
AU - Maruenda, Armando
AU - Maréchal, Hugues
AU - Masala, Alessandro
AU - Mattern, Julia
AU - McFadyen, Charles
AU - McMahon, Catherine
AU - Melegh, Béla
AU - Menovsky, Tomas
AU - Morganti-Kossmann, Cristina
AU - Mulazzi, Davide
AU - Muraleedharan, Visakh
AU - Murray, Lynnette
AU - Mühlan, Holger
AU - Nair, Nandesh
AU - Negru, Ancuta
AU - Nelson, David
AU - Newcombe, Virginia
AU - Nieboer, Daan
AU - Noirhomme, Quentin
AU - Nyirádi, József
AU - Oddo, Mauro
AU - Oldenbeuving, Annemarie
AU - Oresic, Matej
AU - Ortolano, Fabrizio
AU - Palotie, Aarno
AU - Parizel, Paul M.
AU - Patruno, Adriana
AU - Payen, Jean François
AU - Perera, Natascha
AU - Perlbarg, Vincent
AU - Persona, Paolo
AU - Peul, Wilco
AU - Piippo-Karjalainen, Anna
AU - Floury, Sébastien Pili
AU - Pirinen, Matti
AU - Ples, Horia
AU - Poca, Maria Antonia
AU - Polinder, Suzanne
AU - Pomposo, Inigo
AU - Posti, Jussi
AU - Puybasset, Louis
AU - Radoi, Andreea
AU - Ragauskas, Arminas
AU - Raj, Rahul
AU - Rambadagalla, Malinka
AU - Real, Ruben
AU - Rehorčíková, Veronika
AU - Rhodes, Jonathan
AU - Ripatti, Samuli
AU - Rocka, Saulius
AU - Roe, Cecilie
AU - Roise, Olav
AU - Roks, Gerwin
AU - Rosand, Jonathan
AU - Rosenfeld, Jeffrey
AU - Rosenlund, Christina
AU - Rosenthal, Guy
AU - Rossaint, Rolf
AU - Rossi, Sandra
AU - Rueckert, Daniel
AU - Rusnák, Martin
AU - Sacchi, Marco
AU - Sahakian, Barbara
AU - Sahuquillo, Juan
AU - Sakowitz, Oliver
AU - Sala, Francesca
AU - Sanchez-Porras, Renan
AU - Sandor, Janos
AU - Santos, Edgar
AU - Sasu, Luminita
AU - Savo, Davide
AU - Schäffer, Nadine
AU - Schipper, Inger
AU - Schlößer, Barbara
AU - Schmidt, Silke
AU - Schoechl, Herbert
AU - Schoonman, Guus
AU - Schou, Rico Frederik
AU - Schwendenwein, Elisabeth
AU - Schöll, Michael
AU - Sir, Özcan
AU - Skandsen, Toril
AU - Smakman, Lidwien
AU - Smeets, Dirk
AU - Smielewski, Peter
AU - Sorinola, Abayomi
AU - Stamatakis, Emmanuel
AU - Stanworth, Simon
AU - Steinbüchel, Nicole
AU - Stevanovic, Ana
AU - Stevens, Robert
AU - Stewart, William
AU - Steyerberg, Ewout W.
AU - Sundström, Nina
AU - Synnot, Anneliese
AU - Taccone, Fabio Silvio
AU - Takala, Riikka
AU - Tamás, Viktória
AU - Tanskanen, Päivi
AU - Taylor, Mark Steven
AU - Te Ao, Braden
AU - Tenovuo, Olli
AU - Telgmann, Ralph
AU - Teodorani, Guido
AU - Theadom, Alice
AU - Thomas, Matt
AU - Tibboel, Dick
AU - Tolias, Christos
AU - Tshibanda, Jean Flory Luaba
AU - Trapani, Tony
AU - Tudora, Cristina Maria
AU - Vajkoczy, Peter
AU - Vallance, Shirley
AU - Valeinis, Egils
AU - Van Der Steen, Gregory
AU - Van Der Naalt, Joukje
AU - Van Essen, Thomas A.
AU - Van Hecke, Wim
AU - Van Heugten, Caroline
AU - Van Praag, Dominique
AU - Vyvere, Thijs Vande
AU - Van Waesberghe, Julia
AU - Vanhaudenhuyse, Audrey
AU - Vargiolu, Alessia
AU - Vega, Emmanuel
AU - Velt, Kimberley
AU - Verheyden, Jan
AU - Vespa, Paul M.
AU - Vik, Anne
AU - Vilcinis, Rimantas
AU - Vizzino, Giacinta
AU - Vleggeert-Lankamp, Carmen
AU - Volovici, Victor
AU - Voormolen, Daphne
AU - Vulekovic, Peter
AU - Vámos, Zoltán
AU - Wade, Derick
AU - Wang, Kevin K.W.
AU - Wang, Lei
AU - Wessels, Lars
AU - Wildschut, Eno
AU - Williams, Guy
AU - Wilson, Lindsay
AU - Winkler, Maren K.L.
AU - Wolf, Stefan
AU - Ylén, Peter
AU - Younsi, Alexander
AU - Zaaroor, Menashe
AU - Zhihui, Yang
AU - Ziverte, Agate
AU - Zumbo, Fabrizio
N1 - Publisher Copyright: © 2018 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2018/11/16
Y1 - 2018/11/16
N2 - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.
AB - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.
KW - Brain death
KW - Ethics
KW - Postmortem organ donation
KW - Traumatic brain injury
KW - Ventricular drainage
KW - Withdrawing life-sustaining measures
UR - http://www.scopus.com/inward/record.url?scp=85056714365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056714365&partnerID=8YFLogxK
U2 - 10.1186/s13054-018-2241-4
DO - 10.1186/s13054-018-2241-4
M3 - Article
C2 - 30446017
AN - SCOPUS:85056714365
VL - 22
JO - Critical Care
JF - Critical Care
SN - 1364-8535
IS - 1
M1 - 306
ER -