Brain code and coma recovery: Aggressive management of cerebral herniation

Atul A. Kalanuria, Romergryko G. Geocadin, Hans A. Püttgen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Cerebral herniation occurs due to lateral or vertical shifts in brain tissue as a complication of an intra- or extra-axial nervous system pathology. Midline shift of midline brain structures has been independently associated with poor outcome in a variety of neurologic injuries. Herniation may present as a subacute phenomenon constituting mild and progressive alteration of consciousness or as a hyperacute scenario wherein there is rapid decompensation of intracranial compliance. If left uncontrolled, cerebral herniation will lead to destruction of arousal mechanisms and result in a comatose state. A protocol-based approach for the management of herniation has the potential to minimize or reverse these shifts and in conjunction with clinical examination, radiologic data and neuromonitoring techniques offer the option of preventing a second catastrophe. In this article, the authors discuss the mechanisms that lead to coma in brain-herniating patients and the treatment choices that have been successfully used in this patient population.

Original languageEnglish (US)
Pages (from-to)133-141
Number of pages9
JournalSeminars in neurology
Issue number2
StatePublished - Aug 9 2013


  • acute
  • cerebral
  • coma
  • herniation
  • management

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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