Brain changes in schizophrenia. Volumetric MRI study of families multiply affected with schizophrenia - The Maudsley Family Study 5

T. Sharma, E. Lancaster, D. Lee, S. Lewis, T. Sigmundsson, N. Takei, H. Gurling, P. Barta, G. Pearlson, R. Murray

Research output: Contribution to journalArticle

Abstract

Background: Structural brain abnormalities have been reported in schizophrenia. We tested the hypothesis that these abnormalities represented a marker for the genetic liability to schizophrenia in a sample of people with schizophrenia and their relatives from families multiply affected with the disorder. Method: We compared 31 people with schizophrenia, 57 relatives and 39 unrelated control subjects. Volumetric measurement of brain structures was carried out using stereological principles from three-dimensional reconstructed magnetic resonance images. Results: Subjects with schizophrenia had larger lateral ventricles than their relatives and the normal control subjects. Relatives who were 'presumed obligate carriers' had larger left lateral ventricles than other relatives and the control subjects. Subjects with schizophrenia showed smaller whole brain and cerebellar volumes and larger lateral ventricles than their age- and gendermatched unaffected siblings. Conclusions: In families multi ply affected with schizophrenia lateral ventricular enlargement distinguishes people with schizophrenia and presumed obligate carriers from other relatives and unrelated control subjects. These changes may be a marker for a genetic liability to schizophrenia.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalBritish Journal of Psychiatry
Volume173
Issue numberAUG.
DOIs
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Sharma, T., Lancaster, E., Lee, D., Lewis, S., Sigmundsson, T., Takei, N., Gurling, H., Barta, P., Pearlson, G., & Murray, R. (1998). Brain changes in schizophrenia. Volumetric MRI study of families multiply affected with schizophrenia - The Maudsley Family Study 5. British Journal of Psychiatry, 173(AUG.), 132-138. https://doi.org/10.1192/bjp.173.2.132