Brain bioenergetics during cardiopulmonary resuscitation in dogs

S. M. Eleff, C. L. Schleien, R. C. Koehler, D. H. Shaffner, J. Tsitlik, H. R. Halperin, M. C. Rogers, R. J. Traystman

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac arrest causes a rapid loss of cerebral adenosine triphosphatase (ATP) and a decrease in cerebral intracellular pH (pH(i)). Depending on the efficacy of cardiopulmonary resuscitation (CPR), cerebral blood flow levels (CBF) ranging from near zero to near normal have been reported experimentally. Using 31P magnetic resonance spectroscopy, the authors tested whether experimental CPR with normal levels of cerebral blood flow can rapidly restore cerebral ATP and pH(i) despite the progressive systemic acidemia associated with CPR. After 6 min of ventricular fibrillation in six dogs anesthetized with fentanyl and pentobarbital, ATP was reduced to undetectable concentrations and pH(i) decreased from 7.11 ± 0.02 to 6.28 ± 0.09 (± SE) as measured by 31P magnetic resonance spectroscopy. Application of cyclic chest compression by an inflatable vest placed around the thorax and infusion of epinephrine (40 μg/kg bolus plus 8 μg/kg/min, intravenously) maintained cerebral perfusion pressure greater than 70 mmHg for 50 min with the dog remaining in the magnet. Prearrest cerebral blood flows were generated. Cerebral pH(i) recovered to 7.03 ± 0.03 by 35 min of CPR, whereas arterial pH decreased from 7.41 ± 0.4 to 7.08 ± 0.04 and cerebral venous pH decreased from 7.29 ± 0.03 to 7.01 ± 0.04. Cerebral ATP levels recovered to 86 ± 7% (± SE) of prearrest concentration by 6 min of CPR. There was no further recovery of ATP, which remained significantly less than control. Therefore, in contrast to hyperemic reperfusion with spontaneous circulation and full ATP recovery, experimental CPR may not be able to restore ATP completely after 6 min of global ischemia despite restoration of CBF and brain pH(i) to prearrest levels.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalAnesthesiology
Volume76
Issue number1
DOIs
StatePublished - 1992

Keywords

  • Brain: blood flow; metabolism
  • Cardiopulmonary resuscitation
  • Measurement techniques, magnetic resonance spectroscopy: adenosine triphosphatase; inorganic phosphate; pH; phosphocreatine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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