Brain atrophy in Huntington's disease - A CT-scan study

S. E. Starkstein, S. E. Folstein, J. Brandt, G. D. Pearlson, A. McDonnell, M. Folstein

Research output: Contribution to journalArticlepeer-review


CT-scan measurements of cortical and subcortical atrophy were carried out in 34 patients with Huntington's disease (HD). While a significant correlation was observed between parameters of subcortical atrophy (bicaudate ratio, bifrontal ratio and third ventricular ratio) and duration of the disease, there was no significant correlation between these parameters and age. On the other hand, measurements of cortical atrophy (frontal fissure ratio and cortical sulci ratio) correlated significantly with age but not with duration of the disease. When a group of 24 HD patients were compared on CT-scan measurements with a group of 24 age-matched normal controls, significant differences were obtained for all the variables examined, but the bicaudate ratio showed the highest sensitivity and specificity. Even mildly affected patients, with duration of motor symptoms less than 3 years had higher bicaudate ratios than age-matched controls.

Original languageEnglish (US)
Pages (from-to)156-159
Number of pages4
Issue number2
StatePublished - Mar 1989


  • Caudate
  • Corticol atrophy
  • Huntington's disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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