Brain activation in offspring of AD cases corresponds to 10q linkage

Susan Spear Bassett, Ivana Kusevic, Catherine Cristinzio, Michael A. Yassa, Dimitrios Avramopoulos, David M. Yousem, M. Daniele Fallin

Research output: Contribution to journalArticle

Abstract

Previously, we reported evidence of genetic heterogeneity in late-onset familial Alzheimer's disease, based on sex of affected parent, demonstrating linkage to chromosome 10q, a region identified by other groups and implicated as a quantitative trait loci for Aβ levels, in families with an affected mother. Using functional magnetic resonance imaging and a memory encoding task, we now show differential brain activation patterns among asymptomatic offspring which correspond to the previous linkage finding. These results suggest the possibility that activation patterns may prove useful as a preclinical quantitative trait related to the putative familial late-onset AD gene in this chromosome 10 region.

Original languageEnglish (US)
Pages (from-to)142-146
Number of pages5
JournalAnnals of neurology
Volume58
Issue number1
DOIs
StatePublished - Jul 1 2005

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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