BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors

Felix Zeppernick, Laura Ardighieri, Charlotte G. Hannibal, Russell S Vang, Jette Junge, Susanne K. Kjaer, Rugang Zhang, Robert J Kurman, Ie Ming Shih

Research output: Contribution to journalArticle

Abstract

Serous borderline tumor also known as atypical proliferative serous tumor (APST) is the precursor of ovarian lowgrade serous carcinoma (LGSC). In this study, we correlated the morphologic and immunohistochemical phenotypes of 71 APSTs and 18 LGSCs with the mutational status of KRAS and BRAF, the most common molecular genetic changes in these neoplasms. A subset of cells characterized by abundant eosinophilic cytoplasm (EC), discrete cell borders, and bland nuclei was identified in all (100%) 25 BRAF-mutated APSTs but in only 5 (10%) of 46 APSTs without BRAF mutations (P

Original languageEnglish (US)
Pages (from-to)1603-1611
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume38
Issue number12
StatePublished - 2014

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Mutation
Neoplasms
Molecular Biology
Cytoplasm
Carcinoma
Phenotype

Keywords

  • BRAF mutation
  • Low-grade serous carcinoma
  • Ovarian neoplasm
  • Senescence
  • Serous borderline tumors

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

Cite this

BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors. / Zeppernick, Felix; Ardighieri, Laura; Hannibal, Charlotte G.; Vang, Russell S; Junge, Jette; Kjaer, Susanne K.; Zhang, Rugang; Kurman, Robert J; Shih, Ie Ming.

In: American Journal of Surgical Pathology, Vol. 38, No. 12, 2014, p. 1603-1611.

Research output: Contribution to journalArticle

Zeppernick, Felix ; Ardighieri, Laura ; Hannibal, Charlotte G. ; Vang, Russell S ; Junge, Jette ; Kjaer, Susanne K. ; Zhang, Rugang ; Kurman, Robert J ; Shih, Ie Ming. / BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors. In: American Journal of Surgical Pathology. 2014 ; Vol. 38, No. 12. pp. 1603-1611.
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