TY - JOUR
T1 - Bradykinin receptors localized by quantitative autoradiography in kidney, ureter, and bladder
AU - Manning, D. C.
AU - Snyder, S. H.
PY - 1989
Y1 - 1989
N2 - We have localized high affinity [3H]bradykinin receptor binding sites by in vitro autoradiography in kidney, ureter, and bladder of the guinea pig. The peptide pharmacology of the binding sites corresponds to that of high affinity physiological bradykinin receptors previously described (Manning, D.C., R. Vavrek, J.M. Stewart, and S.H. Snyder. J. Pharmacol. Exp. Ther. 237: 504-512, 1986). In the kidney, receptors are concentrated in the medulla with negligible binding in the cortex. Medullary receptors are localized to the interstitium just beneath the basal membrane of collecting tubule cells and between tubules. In the ureter and bladder, receptors are confined to the lamina propria just beneath the epithelial layer. Localizations in the kidney may relate to the diuretic and natriuretic actions of bradykinin. Ureteral and bladder receptors may be associated with a role of bradykinin in pain and inflammation.
AB - We have localized high affinity [3H]bradykinin receptor binding sites by in vitro autoradiography in kidney, ureter, and bladder of the guinea pig. The peptide pharmacology of the binding sites corresponds to that of high affinity physiological bradykinin receptors previously described (Manning, D.C., R. Vavrek, J.M. Stewart, and S.H. Snyder. J. Pharmacol. Exp. Ther. 237: 504-512, 1986). In the kidney, receptors are concentrated in the medulla with negligible binding in the cortex. Medullary receptors are localized to the interstitium just beneath the basal membrane of collecting tubule cells and between tubules. In the ureter and bladder, receptors are confined to the lamina propria just beneath the epithelial layer. Localizations in the kidney may relate to the diuretic and natriuretic actions of bradykinin. Ureteral and bladder receptors may be associated with a role of bradykinin in pain and inflammation.
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U2 - 10.1152/ajprenal.1989.256.5.f909
DO - 10.1152/ajprenal.1989.256.5.f909
M3 - Article
C2 - 2541629
AN - SCOPUS:0024359603
SN - 0002-9513
VL - 256
SP - F909-F915
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
IS - 5 (25/5)
ER -