Bradykinin receptors localized by quantitative autoradiography in kidney, ureter, and bladder

D. C. Manning, S. H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

We have localized high affinity [3H]bradykinin receptor binding sites by in vitro autoradiography in kidney, ureter, and bladder of the guinea pig. The peptide pharmacology of the binding sites corresponds to that of high affinity physiological bradykinin receptors previously described (Manning, D.C., R. Vavrek, J.M. Stewart, and S.H. Snyder. J. Pharmacol. Exp. Ther. 237: 504-512, 1986). In the kidney, receptors are concentrated in the medulla with negligible binding in the cortex. Medullary receptors are localized to the interstitium just beneath the basal membrane of collecting tubule cells and between tubules. In the ureter and bladder, receptors are confined to the lamina propria just beneath the epithelial layer. Localizations in the kidney may relate to the diuretic and natriuretic actions of bradykinin. Ureteral and bladder receptors may be associated with a role of bradykinin in pain and inflammation.

Original languageEnglish (US)
Pages (from-to)F909-F915
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume256
Issue number5 (25/5)
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Bradykinin receptors localized by quantitative autoradiography in kidney, ureter, and bladder'. Together they form a unique fingerprint.

Cite this