Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain

F. M A Correa, R. B. Innis, G. R. Uhl, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Bradykinin-like immunoreactive structures were localized in rat brain by the indirect immunofluorescence method. Specificity of staining was demonstrated by: (i) the absence of fluorescence when preimmune serum was used, (ii) the disappearance of fluorescence when sera were preadsorbed with bradykinin, and (iii) the presence of identical staining with two different antisera. Immunoreactive neuronal cells are observed only in the hypothalamus, with especially dense clusters overlying the periventricular and dorsomedial nuclei. Fibers and varicose processes are observed in the periaqueductal gray matter, hypothalamus, perirhinal and cingulate cortices, the ventral portion of caudate-putamen and the lateral septal area.

Original languageEnglish (US)
Pages (from-to)1489-1493
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number3
StatePublished - 1979

Fingerprint

Bradykinin
Hypothalamus
Fluorescence
Staining and Labeling
Septum of Brain
Mediodorsal Thalamic Nucleus
Periaqueductal Gray
Putamen
Gyrus Cinguli
Brain
Indirect Fluorescent Antibody Technique
Serum
Immune Sera
Perirhinal Cortex

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain. / Correa, F. M A; Innis, R. B.; Uhl, G. R.; Snyder, Solomon H.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 76, No. 3, 1979, p. 1489-1493.

Research output: Contribution to journalArticle

@article{6f6950666e3747cd9ad53872ee246e4b,
title = "Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain",
abstract = "Bradykinin-like immunoreactive structures were localized in rat brain by the indirect immunofluorescence method. Specificity of staining was demonstrated by: (i) the absence of fluorescence when preimmune serum was used, (ii) the disappearance of fluorescence when sera were preadsorbed with bradykinin, and (iii) the presence of identical staining with two different antisera. Immunoreactive neuronal cells are observed only in the hypothalamus, with especially dense clusters overlying the periventricular and dorsomedial nuclei. Fibers and varicose processes are observed in the periaqueductal gray matter, hypothalamus, perirhinal and cingulate cortices, the ventral portion of caudate-putamen and the lateral septal area.",
author = "Correa, {F. M A} and Innis, {R. B.} and Uhl, {G. R.} and Snyder, {Solomon H}",
year = "1979",
language = "English (US)",
volume = "76",
pages = "1489--1493",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "3",

}

TY - JOUR

T1 - Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain

AU - Correa, F. M A

AU - Innis, R. B.

AU - Uhl, G. R.

AU - Snyder, Solomon H

PY - 1979

Y1 - 1979

N2 - Bradykinin-like immunoreactive structures were localized in rat brain by the indirect immunofluorescence method. Specificity of staining was demonstrated by: (i) the absence of fluorescence when preimmune serum was used, (ii) the disappearance of fluorescence when sera were preadsorbed with bradykinin, and (iii) the presence of identical staining with two different antisera. Immunoreactive neuronal cells are observed only in the hypothalamus, with especially dense clusters overlying the periventricular and dorsomedial nuclei. Fibers and varicose processes are observed in the periaqueductal gray matter, hypothalamus, perirhinal and cingulate cortices, the ventral portion of caudate-putamen and the lateral septal area.

AB - Bradykinin-like immunoreactive structures were localized in rat brain by the indirect immunofluorescence method. Specificity of staining was demonstrated by: (i) the absence of fluorescence when preimmune serum was used, (ii) the disappearance of fluorescence when sera were preadsorbed with bradykinin, and (iii) the presence of identical staining with two different antisera. Immunoreactive neuronal cells are observed only in the hypothalamus, with especially dense clusters overlying the periventricular and dorsomedial nuclei. Fibers and varicose processes are observed in the periaqueductal gray matter, hypothalamus, perirhinal and cingulate cortices, the ventral portion of caudate-putamen and the lateral septal area.

UR - http://www.scopus.com/inward/record.url?scp=0018349078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018349078&partnerID=8YFLogxK

M3 - Article

C2 - 375238

AN - SCOPUS:0018349078

VL - 76

SP - 1489

EP - 1493

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 3

ER -