Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions

L. R. Steranka, D. C. Manning, C. J. DeHaas, J. W. Ferkany, S. A. Borosky, J. R. Connor, R. J. Vavrek, J. M. Stewart, S. H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.

Original languageEnglish (US)
Pages (from-to)3245-3249
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number9
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • General

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