Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions

L. R. Steranka; D. C. Manning; C. J. DeHaas; J. W. Ferkany; S. A. Borosky; J. R. Connor; R. J. Vavrek; J. M. Stewart; S. H. Snyder

doi:10.1073/pnas.85.9.3245

Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions

L. R. Steranka, D. C. Manning, C. J. DeHaas, J. W. Ferkany, S. A. Borosky, J. R. Connor, R. J. Vavrek, J. M. Stewart, S. H. Snyder

Research output: Contribution to journal › Article › peer-review

356 Scopus citations

Abstract

Autoradiographic studies localize [³H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [³H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [³H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.

Original language	English (US)
Pages (from-to)	3245-3249
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	85
Issue number	9
DOIs	https://doi.org/10.1073/pnas.85.9.3245
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.85.9.3245

Cite this

Steranka, L. R., Manning, D. C., DeHaas, C. J., Ferkany, J. W., Borosky, S. A., Connor, J. R., Vavrek, R. J., Stewart, J. M., & Snyder, S. H. (1988). Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions. Proceedings of the National Academy of Sciences of the United States of America, 85(9), 3245-3249. https://doi.org/10.1073/pnas.85.9.3245

Steranka, LR, Manning, DC, DeHaas, CJ, Ferkany, JW, Borosky, SA, Connor, JR, Vavrek, RJ, Stewart, JM & Snyder, SH 1988, 'Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions', Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 9, pp. 3245-3249. https://doi.org/10.1073/pnas.85.9.3245

@article{292082f3d1b84389978fca195a0dc9f3,

title = "Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions",

abstract = "Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.",

author = "Steranka, {L. R.} and Manning, {D. C.} and DeHaas, {C. J.} and Ferkany, {J. W.} and Borosky, {S. A.} and Connor, {J. R.} and Vavrek, {R. J.} and Stewart, {J. M.} and Snyder, {S. H.}",

year = "1988",

doi = "10.1073/pnas.85.9.3245",

language = "English (US)",

volume = "85",

pages = "3245--3249",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "9",

}

TY - JOUR

T1 - Bradykinin as a pain mediator

T2 - Receptors are localized to sensory neurons, and antagonists have analgesic actions

AU - Steranka, L. R.

AU - Manning, D. C.

AU - DeHaas, C. J.

AU - Ferkany, J. W.

AU - Borosky, S. A.

AU - Connor, J. R.

AU - Vavrek, R. J.

AU - Stewart, J. M.

AU - Snyder, S. H.

PY - 1988

Y1 - 1988

N2 - Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.

AB - Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.

UR - http://www.scopus.com/inward/record.url?scp=0001240428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001240428&partnerID=8YFLogxK

U2 - 10.1073/pnas.85.9.3245

DO - 10.1073/pnas.85.9.3245

M3 - Article

C2 - 2896357

AN - SCOPUS:0001240428

SN - 0027-8424

VL - 85

SP - 3245

EP - 3249

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 9

ER -

Bradykinin as a pain mediator: Receptors are localized to sensory neurons, and antagonists have analgesic actions

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this