Bradykinin analogues: differential agonist and antagonist activities suggesting multiple receptors

Karen M. Braas, Donald C. Manning, David C. Perry, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Bradykinin analogues with specific antagonist activity in several bioassays were evaluated for effects on [3H]‐bradykinin receptor binding sites and inositol phosphate production in neuroblastoma N1E‐115 cells. The analogues varied in their affinities for bradykinin receptors in guinea‐pig ileum and N1E‐115 cell membranes, in their effects on uterine and ileal contractions and in their agonist or antagonist activity on phosphoinositide turnover in N1E‐115 cells. These tissue specific effects suggest the presence of multiple bradykinin receptor subtypes. 1988 British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)3-5
Number of pages3
JournalBritish Journal of Pharmacology
Volume94
Issue number1
DOIs
StatePublished - May 1988

ASJC Scopus subject areas

  • Pharmacology

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