Bovine papillomavirus type 1 monoclonal antibodies

J. B. Gorra, W. D. Lancaster, R. J. Kurman, A. B. Jenson

Research output: Contribution to journalArticlepeer-review

Abstract

Bovine papillomavirus type 1 (BPV-1) and type 2 (BPV-2) are the etiologic agents of fibropapillomas in cattle. Polyclonal antisera produced against BPV-1 structural antigens are cross-reactive with BPV-2. In this study BPV-1 type-specific monoclonal antibodies were produced that were not reactive with BPV-2. These monoclonal antibodies could be used for identification of BPV-1 structural antigens in acetone-fixed, frozen sections by immunofluorescence and Formalin-fixed, paraffin-embedded sections by immunoperoxidase techniques. In addition, these antibodies could be used for identification and purification of BPV-1 virions by immune electron microscopy and immunoadsorption techniques, respectively.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalJournal of the National Cancer Institute
Volume75
Issue number1
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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