Abstract
The mitotic checkpoint is a major cell cycle control mechanism that guards against chromosome missegregation and the subsequent production of aneuploid daughter cells. Most cancer cells are aneuploid and frequently missegregate chromosomes during mitosis. Indeed, aneuploidy is a common characteristic of tumours, and, for over 100 years, it has been proposed to drive tumour progression. However, recent evidence has revealed that although aneuploidy can increase the potential for cellular transformation, it also acts to antagonize tumorigenesis in certain genetic contexts. A clearer understanding of the tumour suppressive function of aneuploidy might reveal new avenues for anticancer therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 478-487 |
| Number of pages | 10 |
| Journal | Nature Reviews Molecular Cell Biology |
| Volume | 10 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2009 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
Cite this
Boveri revisited : Chromosomal instability, aneuploidy and tumorigenesis. / Holland, Andrew; Cleveland, Don W.
In: Nature Reviews Molecular Cell Biology, Vol. 10, No. 7, 07.2009, p. 478-487.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Boveri revisited
T2 - Chromosomal instability, aneuploidy and tumorigenesis
AU - Holland, Andrew
AU - Cleveland, Don W.
PY - 2009/7
Y1 - 2009/7
N2 - The mitotic checkpoint is a major cell cycle control mechanism that guards against chromosome missegregation and the subsequent production of aneuploid daughter cells. Most cancer cells are aneuploid and frequently missegregate chromosomes during mitosis. Indeed, aneuploidy is a common characteristic of tumours, and, for over 100 years, it has been proposed to drive tumour progression. However, recent evidence has revealed that although aneuploidy can increase the potential for cellular transformation, it also acts to antagonize tumorigenesis in certain genetic contexts. A clearer understanding of the tumour suppressive function of aneuploidy might reveal new avenues for anticancer therapy.
AB - The mitotic checkpoint is a major cell cycle control mechanism that guards against chromosome missegregation and the subsequent production of aneuploid daughter cells. Most cancer cells are aneuploid and frequently missegregate chromosomes during mitosis. Indeed, aneuploidy is a common characteristic of tumours, and, for over 100 years, it has been proposed to drive tumour progression. However, recent evidence has revealed that although aneuploidy can increase the potential for cellular transformation, it also acts to antagonize tumorigenesis in certain genetic contexts. A clearer understanding of the tumour suppressive function of aneuploidy might reveal new avenues for anticancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=67649522162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649522162&partnerID=8YFLogxK
U2 - 10.1038/nrm2718
DO - 10.1038/nrm2718
M3 - Article
C2 - 19546858
AN - SCOPUS:67649522162
VL - 10
SP - 478
EP - 487
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
SN - 1471-0072
IS - 7
ER -