Boundary-based warping of brain MR images

The goal of this work was to develop a warping technique for mapping a brain image to another image or atlas data, with minimum user interaction and independent of gray level information. We have developed and tested three different methods for warping MR brain images. We utilize a deformable contour to extract and warp the boundaries of the two images. A mesh-grid coordinate system is constructed for each brain, by applying a distance transformation to the resulting contours, and scaling. In the first method (MGC), the first image is mapped to the second image based on a one-to-one mapping between different layers defined by the mesh-grid. In the second method (IDW), the corresponding pixels in the two images are found using the above mesh-grid system and a local inverse-distance weights interpolation. In the third proposed method (TSB), a subset of grid points is used for finding the parameters of a spline transformation, which defines the global warping. The warping methods were applied to clinical MR consisting of diffusion weighted and T2 weighted images of the human brain. The IDW and TSB methods were superior in ranking of diagnostic quality of the warped MR images to the MGC (p<0.01) as defined by a neuroradiologist. The deformable contour warping produced excellent diagnostic quality for the diffusion-weighted images co-registered and warped to T2 weighted images.