Abstract
Introduction: Onabotulinum toxin A is an effective treatment for a variety of movement disorders; yet, results of efficacy in patients with medically-resistant tic disorders are insufficient. We aimed to assess the efficacy of Onabotulinum toxin A in patients with ocular tics in an observational study. Methods: Patients with ocular tics, regularly treated with Onabotulinum toxin A injections at our clinic, were enrolled for 2 visits, one of which was for baseline assessment and a single injection session and the second -a follow-up visit one month after treatment for evaluation of outcome. The assessment tools consisted of a 10-minute videotape recording which was scored later by a blinded rater. The calculated ocular tic frequency was the primary end-point of this study. Secondary outcome measures consisted of additional items obtained from the video recording as well as the motor subset of the Yale Global Tic Severity Scale (YGTSS-M) and the Clinical Global Impression of change (CGI-C). Results: Six patients were enrolled.Video recordings and rating of the ocular tics before and after treatment revealed a 37% reduction in mean tic frequency, a 2.18-fold prolongation of the time to the first tic following suppression and a reduction in tic frequency during and after suppression by 45% and 52%, respectively. The mean YGTSS-M decreased by 39%. Five patients reported an improvement in CGI-C while one reported no change. Conclusions: In this observational study, Onabotulinum toxin A was found to be an effective treatment for ocular tics, providing both subjective and objective benefit for a subset of patients.
Original language | English (US) |
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Pages (from-to) | 9-11 |
Number of pages | 3 |
Journal | Open Neurosurgery Journal |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Keywords
- Botulinum toxin
- Efficacy
- Ocular tics
- Tic disorder
ASJC Scopus subject areas
- Surgery
- Clinical Neurology