Boronated thymidine analogues for boron neutron capture therapy

B. Thirumamagal, Jayaseharan Johnsamuel, Guirec Cosquer, Youngjoo Byun, Junhua Yan, Sureshbabu Narayanasamy, Werner Tjarks, Rolf Barth, Ashraf Al-Madhoun, Staffan Eriksson

Research output: Contribution to journalArticlepeer-review

Abstract

Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.

Original languageEnglish (US)
Pages (from-to)861-866
Number of pages6
JournalNucleosides, Nucleotides and Nucleic Acids
Volume25
Issue number8
DOIs
StatePublished - Sep 1 2006
Externally publishedYes

Keywords

  • 3-Carboranyl Thymidine Analogues (3CTAs)
  • Boron Neutron Capture Therapy (BNCT)

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

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