Borna disease virus: nature of the etiologic agent and significance of infection in man.

J. A. Richt; S. Herzog; J. Pyper; J. E. Clements; O. Narayan; K. Bechter; R. Rott

doi:10.1007/978-3-7091-9300-6_9

Borna disease virus: nature of the etiologic agent and significance of infection in man.

J. A. Richt, S. Herzog, J. Pyper, J. E. Clements, O. Narayan, K. Bechter, R. Rott

Research output: Contribution to journal › Review article › peer-review

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Abstract

This review presents data on the characterization of Borna disease virus (BDV) and its potential as a possible causative agent in humans. The isolation of: (i) BDV-specific cDNA clones that encode various BDV-specific proteins and (ii) partially purified virus particles led to the conclusion that the viral genome consists of negative-sense, single-stranded RNA. The organization of the BDV-specific RNA species appears to be a nested set of overlapping subgenomic RNA transcripts. Furthermore, evidence is presented that BDV can infect humans and may cause certain psychiatric and neurological disorders. This concept is supported by: (i) the finding of virus-specific antibodies in sera of patients with neuropsychiatric diseases and (ii) results obtained during attempts to isolate BDV or a BDV-related agent from the cerebrospinal fluid of seropositive patients.

Original language	English (US)
Pages (from-to)	101-109
Number of pages	9
Journal	Archives of virology. Supplementum
Volume	7
DOIs	https://doi.org/10.1007/978-3-7091-9300-6_9
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

General Immunology and Microbiology

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10.1007/978-3-7091-9300-6_9

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title = "Borna disease virus: nature of the etiologic agent and significance of infection in man.",

abstract = "This review presents data on the characterization of Borna disease virus (BDV) and its potential as a possible causative agent in humans. The isolation of: (i) BDV-specific cDNA clones that encode various BDV-specific proteins and (ii) partially purified virus particles led to the conclusion that the viral genome consists of negative-sense, single-stranded RNA. The organization of the BDV-specific RNA species appears to be a nested set of overlapping subgenomic RNA transcripts. Furthermore, evidence is presented that BDV can infect humans and may cause certain psychiatric and neurological disorders. This concept is supported by: (i) the finding of virus-specific antibodies in sera of patients with neuropsychiatric diseases and (ii) results obtained during attempts to isolate BDV or a BDV-related agent from the cerebrospinal fluid of seropositive patients.",

author = "Richt, {J. A.} and S. Herzog and J. Pyper and Clements, {J. E.} and O. Narayan and K. Bechter and R. Rott",

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T1 - Borna disease virus

T2 - nature of the etiologic agent and significance of infection in man.

AU - Richt, J. A.

AU - Herzog, S.

AU - Pyper, J.

AU - Clements, J. E.

AU - Narayan, O.

AU - Bechter, K.

AU - Rott, R.

PY - 1993

Y1 - 1993

N2 - This review presents data on the characterization of Borna disease virus (BDV) and its potential as a possible causative agent in humans. The isolation of: (i) BDV-specific cDNA clones that encode various BDV-specific proteins and (ii) partially purified virus particles led to the conclusion that the viral genome consists of negative-sense, single-stranded RNA. The organization of the BDV-specific RNA species appears to be a nested set of overlapping subgenomic RNA transcripts. Furthermore, evidence is presented that BDV can infect humans and may cause certain psychiatric and neurological disorders. This concept is supported by: (i) the finding of virus-specific antibodies in sera of patients with neuropsychiatric diseases and (ii) results obtained during attempts to isolate BDV or a BDV-related agent from the cerebrospinal fluid of seropositive patients.

AB - This review presents data on the characterization of Borna disease virus (BDV) and its potential as a possible causative agent in humans. The isolation of: (i) BDV-specific cDNA clones that encode various BDV-specific proteins and (ii) partially purified virus particles led to the conclusion that the viral genome consists of negative-sense, single-stranded RNA. The organization of the BDV-specific RNA species appears to be a nested set of overlapping subgenomic RNA transcripts. Furthermore, evidence is presented that BDV can infect humans and may cause certain psychiatric and neurological disorders. This concept is supported by: (i) the finding of virus-specific antibodies in sera of patients with neuropsychiatric diseases and (ii) results obtained during attempts to isolate BDV or a BDV-related agent from the cerebrospinal fluid of seropositive patients.

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JO - Archives of virology. Supplementum

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ER -

Borna disease virus: nature of the etiologic agent and significance of infection in man.

Abstract

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