Borna disease virus: nature of the etiologic agent and significance of infection in man.

J. A. Richt, S. Herzog, J. Pyper, J. E. Clements, O. Narayan, K. Bechter, R. Rott

Research output: Contribution to journalReview articlepeer-review

Abstract

This review presents data on the characterization of Borna disease virus (BDV) and its potential as a possible causative agent in humans. The isolation of: (i) BDV-specific cDNA clones that encode various BDV-specific proteins and (ii) partially purified virus particles led to the conclusion that the viral genome consists of negative-sense, single-stranded RNA. The organization of the BDV-specific RNA species appears to be a nested set of overlapping subgenomic RNA transcripts. Furthermore, evidence is presented that BDV can infect humans and may cause certain psychiatric and neurological disorders. This concept is supported by: (i) the finding of virus-specific antibodies in sera of patients with neuropsychiatric diseases and (ii) results obtained during attempts to isolate BDV or a BDV-related agent from the cerebrospinal fluid of seropositive patients.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalArchives of virology. Supplementum
Volume7
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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