Borna disease: Virus-induced neurobehavioral disease pathogenesis

Kathryn M. Carbone, Steven A. Rubin, Yoshii Nishino, Mikhail V. Pletnikov

Research output: Contribution to journalReview articlepeer-review

Abstract

Studies of the pathogenesis of neurobehavioral diseases following Borna disease virus infections have been increasing rapidly over the past ten years. Recent major advances have included a report of vertical transmission of the virus in its natural host, the horse, and a report of isolation of a novel variant, No/98, in that same species. In rats infected neonatally with the Borna disease virus that lack blood-borne inflammation in the brain, evidence of an 'endogenous' brain inflammatory response is abundant, with elevated expression of cytokine and chemokine mRNA. Infection in these rats is also associated with abnormal levels of neurotransmitters, including serotonin and norepinephrine. Data and debate continue to be forthcoming about the role of Borna disease virus in human infection and psychiatric disease.

Original languageEnglish (US)
Pages (from-to)467-475
Number of pages9
JournalCurrent Opinion in Microbiology
Volume4
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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