Borna disease: Association with a maturation defect in the cellular immune response

K. M. Carbone, S. W. Park, S. A. Rubin, R. W. Waltrip, G. B. Vogelsang

Research output: Contribution to journalArticle

Abstract

Borna disease virus (BDV) is a negative-strand RNA virus which produces persistent infection in a variety of experimental animals. In the rat, the presence or absence of clinical signs of Borna disease, a characteristic, biphasic neurobehavioral illness, depends on host-related factors. A window of opportunity exists after birth wherein inoculation with BDV produces a persistently infected rat without signs of Borna disease or encephalitis (persistent, tolerant infection-newborn [PTI-NB] rat). Although immunopathological destruction of the nervous system does not occur in the PTI-NB rat, significant alterations in the development of the nervous system were noted, including site-specific lysis of neurons. Unlike the case with other pharmacologically produced, persistent, tolerant BDV infections, adoptive transfer of spleen cells from BDV-infected rats did not produce disease in the PTI-NB rats. PTI-NB rats developed Borna disease after being connected by parabiosis to rats with Borna disease. Bone marrow transplantation experiments revealed that bone marrow cells from PTI-NB rats produced Borna disease in lethally irradiated, BDV-infected recipient rats. Bone marrow from PTI-NB rats contained a complement of inflammatory cells capable of inducing Borna disease. Thus, the loss of BDV-specific cellular immunity appeared to occur after the release of cells from the bone marrow.

Original languageEnglish (US)
Pages (from-to)6154-6164
Number of pages11
JournalJournal of virology
Volume65
Issue number11
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Carbone, K. M., Park, S. W., Rubin, S. A., Waltrip, R. W., & Vogelsang, G. B. (1991). Borna disease: Association with a maturation defect in the cellular immune response. Journal of virology, 65(11), 6154-6164.