TY - GEN
T1 - Bootstrap Bayesian analysis with applications to gene-environment interaction
AU - Crainiceanu, Adina
AU - Liang, Kung Yee
AU - Crainiceanu, Ciprian M.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - We propose a novel statistical model and inferential algorithm for gene environment interaction. Our methodology was motivated by and applied to identity by descent (IBD) sharing for sibling pairs affected by schizophrenia. Our analysis confirms some of the previous findings on the same data set, e.g. the estimated location of the disease gene and the existence of the interaction between the location of disease gene and environment. Our analysis also provides new insights by better accounting for overall variability in the data. We show that taking into account sampling variability may increase the length of posterior credible intervals for the true location of the disease gene by as much as 140%. Moreover, the posterior distribution is shown to be non-Gaussian, which more closely matches the data.
AB - We propose a novel statistical model and inferential algorithm for gene environment interaction. Our methodology was motivated by and applied to identity by descent (IBD) sharing for sibling pairs affected by schizophrenia. Our analysis confirms some of the previous findings on the same data set, e.g. the estimated location of the disease gene and the existence of the interaction between the location of disease gene and environment. Our analysis also provides new insights by better accounting for overall variability in the data. We show that taking into account sampling variability may increase the length of posterior credible intervals for the true location of the disease gene by as much as 140%. Moreover, the posterior distribution is shown to be non-Gaussian, which more closely matches the data.
UR - http://www.scopus.com/inward/record.url?scp=73949127069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73949127069&partnerID=8YFLogxK
U2 - 10.1109/ISCIS.2009.5291900
DO - 10.1109/ISCIS.2009.5291900
M3 - Conference contribution
AN - SCOPUS:73949127069
SN - 9781424450237
T3 - 2009 24th International Symposium on Computer and Information Sciences, ISCIS 2009
SP - 651
EP - 656
BT - 2009 24th International Symposium on Computer and Information Sciences, ISCIS 2009
T2 - 2009 24th International Symposium on Computer and Information Sciences, ISCIS 2009
Y2 - 14 September 2009 through 16 September 2009
ER -